All undesirable side-effects of Rue seed/extract goes away as the reverse tolerance builds up. I was taking strong/heavy Rue dosages daily for 5 months, it got to a point where it felt so clean on the body, no nausea/vomiting/diarrhea, body load cleaned up fine, got pretty high up on the dosage (enough to cause some tremoring, which told me i needed to back the dosage down a bit).

Also Rue isn't toxic. And Rue doesn't cause vasoconstriction, it causes vasodilation, which can cause a bit of low blood pressure and a headache. Dunno why you're getting red facial skin though unless it's like a flushing or something. There's definitely not any Tyramine issues with Rue, and SS wouldn't happen with just the Rue.

What about mixing both Rue and Caapi? I hear it's great.

As for raw vs extract. I dunno about Caapi. But with Rue, i can tell a difference between ingesting the ground seed in capsules and ingesting the full spectrum extract or purified Harmala extract in capsules. The ground seed feels more raw, fuller, which i actually kinda like. The extract feels a bit lighter/cleaner but is closer to raw Rue than purified Harmalas are, which purified Harmala extract feels quite clean but doesn't feel much like the Rue.