The only thing i've noticed from higher Rue or Harmala dosages is more sedation/relaxation and body load, but other than that it doesn't seem much different than usual/common dosages, ime. When using purified Harmalas, it just feels like Harmaline and some Harmine. There are some differences between Rue seed/extract and purified Harmalas, i think i much prefer the Rue over the purified Harmalas.

As for mixing Caapi and Rue, there are those that prefer one or the other, but if combining them, it's best to find the right dosage for each so that they synergize with each other rather than one overpowering the other, find a more balanced dosage between the two. Combining the two is a cool idea because the Caapi will add more Harmine and THH to Rue's Harmaline and Harmine.