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Exp. Report New favorite substance for me: O-PCE

Experience report

The Traveler

The Moxylator
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As you all know, besides DMT, Moxy has been my favorite substance for a long time, even much so that I dare to say I am probably the person that has the most experience with Moxy on this planet, and who knows the whole universe. šŸ˜‡


That aside, I found another substance that took me further then I ever could imagine before, even with DMT in mind: O-PCE.


First note of warning though: You have to be VERY carefully with dosing this substance, this since dosing too high can quickly turn into a mania-like journey, where you might come into a situation where you hurt yourself or others by accident, you do not not know anymore what reality is, and it's not like a delirium, just that the substance removes you from this universe and takes you to another one where you have NO clue what is happening and how to make sense of it anymore.

There is a
fatality case with this substance! Though never on it's own, always taken together with multiple other substances. Any substance that can help cause serotonine syndrome is probably VERY dangerous with this substance!

A Fatal Case Involving N-Ethyldeschloroketamine (2-Oxo-PCE) and Venlafaxine

Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE (no deaths, though 56 total cases!)

A combined toxicokinetic and metabolic approach to investigate deschloro-N-ethylketamine exposure in a multidrug user (no deaths either, just that O-PCE was also used in the multidrug user, with some interesting information about possible health implications)


Now back to my new favorite substance: O-PCE.

It's a dissociative, that unlike any other dissociative I've ever taken, has extremely profound psychedelics effects, it goes FAR beyond the well known K-hole, and like I said before: it removed you from this universe to propel you into a new one, and dear me, they is just fascinating! No entities, though very visual and with a lot of structures in all sorts and sizes.

I have been swirled into a pink stormy ocean, lifted into a room that looked like I just stepped out of a simulation ("welcome back Traveler, we hope you liked our total immersion VR"), and all the while with my rational mind being unable to even try to make sense of any of it.

Also, unlike many psychedelics, it has no fear for me when I take a dose high enough to be lifted into the O-PCE reality-space, one 30mg capsule taken orally is for me the usual dose, topped up when it starts with one or two extra 10mg capsules, depending on how I feel. It's a pretty smooth ride that keeps you being wondered about what you are observing. I have tried opening my eyes and closing my eyes in a very dark room, and only when the dose is not high enough and when I switched on a tiny light could I make a reality check to see if I was still in my bed at my own home.


It only got very scared once, where I became very reckless and dosed about 4 times the normal dose, just to see where that would bring me. With this high dose you have to understand that this also means I have tried the triple dose before, and unlike the quattro one, that triple one was a very interesting ride! With 4 times the normal dosis though I got into some sort of mania, not a delirium per se, where I was not sure if I could have overdosed or not, I could not rationalize what I had done and screamed for my wife to please help me, even though I knew that no people had died from taking O-PCE alone, I still did not want to be the first one.

After drinking a bit of water, all lights went out for me and I dropped completely unconsciously, that was the moment my wife called the emergency services, they helped her really well, and an ambulance was called. I do not recall the ambulance coming over, neither the ride to the hospital, and neither the handing over in the hospital, my wife just said they were all VERY kind people, and the medics told right away that no police would be involved since I was non aggressive (duh, I was totally knocked out) and in NL it just does not make sense to call the police if there is no need for it, they have many better things to do.

The first time I woke up was in the hospital, and when looking around I was extremely confused, since there was simply NOBODY around, all quiet, you could not even hear a whisper, and then when I looked up I saw some beautifully arranged bright lights in a large square, all clean and smooth, and that is where I thought that I might have woken up from being in a simulator ("welcome back Trav!"), it just made total sense to my non-functional frontal lobes.

Quickly after that a complete team of medical personnel arrived, and after that they took a blood sample to check what substance I could have taken, and send that to the lab. In the meantime, my wife told the medical staff about my work with entheogens, the DMT-Nexus, the science and the harm reductions responsibilities coming with it, and the reason why I take this journeys: so I can provide you with information on what to do and especially what NOT to do (yeah, great job Trav!), This however made a profound change in the mindset of the leading doctor, and he strictly ordered that I would be treated with utmost respect, and that they had to be very gentle with me, and keep score of lots of data to work with me later on.

After that came the full IC care treatment, heart electrodes, infusion, oxygen meter, the whole technical suite and.... including putting me in my own private IC room!

In that room is where I woke up a second time and it was absolutely unreal, I was still tripping sooooooo hard, and there was this constant fresh airstream, a bed that was nice and with the way they can move each part of the mattress for your comfort, they set it exactly right for me, they attached an urinating tube as well, so no worries in that department, and I was being monitored 24/7 for my safety and welbeing.

Now one special request: Please, like REALLY please, NEVER tell this to me wife, since this was very traumatic to her!

However, for me, this was THE MOST ULTIMATE JOURNEY SPOT I have ever been in to trip on any substance, I felt safe, all was kept in just the right temperature for me, no sweaty stuff due to that extremely sufficient overpressure air circulation, so also no outside allergies possible, I could order drinks with just a click on the attention button for a nurse to show up, and for me it was just heaven since I was still tripping the literal balls to the walls with no end in sight, while feeling extremely happy, comfortable, safe and attended too.

I took that 4 times the normal dose around 3:00AM in the night from Saturday to Sunday, and they stated I would be released Sunday at 19:00 (7PM), when I entered the IC it must have been 10:00AM or so.

My brother also came to visit me, To support me and to help me getting home after I would be released (thank you so much for this all my brother!). Between 13:00 (1PM) and 19:00 (7PM) my brother and my wife went back to our home, to hike a bit, talk things over and have a nice hike to clean up their heads. So for about 6 hours I could slowly come down from my extreme journey, in that in the most pleasant way, so for those 6 hours I enjoyed every moment of it, I had a nice meal, once in a while another solid fruit/water drink, and in between when I was a bit more approachable, I had essentially some very interesting discussions with the hospital staff.

Around 19:00 (7PM), my wife and brother showed up again, I wobbled out of bed (still a bit in the disso robot-walk fashion), dressed up and checked out, after which my brother drove me home and I wend straight to bed. I recall while reading my eReader in bed, that vivid OEV's would still spontaneously pop-up next to my eReader, that is how heavy the dose was that I had taken.


So, that was the 'harsh' part of it, in the hopes of making sure sure you will all be relatively careful with a substance like this.

Once I learned to better dose, like preparing all capsules beforehand: 1 with 30mg, and two others with 10mg when I would like to go deeper. That way, without tolerance, I can go very deep, without going that silly 4 times the 30mg dose, traumatizing people around me and putting a non-essential burden on the health-care system.

Since then I have moved on with further discovering the O-PCE reality-space, and with that exploration two special things really stuck out after a while, two things that I never had on any other of the 80+ substance I ever took:

  1. Total recall of ANY music I ever heard, I could play it in my head like just from a radio, mix it with any other music I knew, and just generally just play with it like I was a master mixer in some studio. The sound quality was just gorgeous.

  2. After hours of tripping, I could do that same thing with visuals! I could just visualize anything I was creative enough to imagine, and it was just there as in real life, moving and behaving just like the real thing, and not just a visual, no, a true real life hallucination as if it was there, no difference as to how I would observe that same thing in real life. For me it's something amazing to be able to do, I never could have imagined this was even a possibity!

So, after this long piece of text, you might get a clue as to why this substance is so interesting for me. The biggest drawback is that if you take as lot, like 60mg total, the next day you are pretty fuzzy in your head, you cannot remember much and forget a lot of simple things, the other thing is that you do a bit of the drunk duck waggling the rest of your waking day. The day after that however, it's completely over, and the afterglow of the substance is lingering for quite as few days.

Another thing that I must warn you for is that it has seemingly the same effects on your bladder as ketamine, and even though you take a much lower dose than you would normally take for something like ketamine to K-hole, it's still more than nothing. And in the hospital they (and I) could easily see the dark "flocks" in my urine samples. I am not sure how harmful they are, thankfully I have no bladder issues, but it can be that you might be more sensitive, so please be careful and if needed let your bladder get monitored regularly.

So now I have three favorite substances:
1. DMT
2. Moxy
3. O-PCE

With my vivid story posted here I hope you all got some solid information out of this trip report, and I'll be happy to answer any genuine question. I will be exploring this substance for a loooooong time to come, and this time safely, I have learned to navigate O-PCE reality-space. <3


Kind regards,

The Traveler
 
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Man oh man... that was a wild story.. wild ride!

Glad it worked out for you, I mean it sounds like you even found a way to just enjoy the insanity of it all. Hearty psychonaut you are! I would be interested in trying this out safely as you stated. Someone had to go first I suppose, you came out the other side none worse for ware and learned from the experience.

Thank you for sharing your experience!
 
Glad you're okay. Had a friend die on LSD. Must have taken a large dose, thought he was dying, his gf was scared, called an ambulance. He might have been unconscious and regained it in the ambulance... idk but supposedly he escaped the ambulance and jumped off an overpass. :(
 
Glad you're okay. Had a friend die on LSD. Must have taken a large dose, thought he was dying, his gf was scared, called an ambulance. He might have been unconscious and regained it in the ambulance... idk but supposedly he escaped the ambulance and jumped off an overpass. :(
So sorry to hear about your friend.

Thankfully on a high dose of O-PCE you have the pace of utmost a slow turtle, while wiggling on your feet like a duck that sipped too much vodka. So escaping an ambulance (or hospital) is pretty much impossible on a high dose O-PCE.


Kind regards,

The Traveler
 
Holy moley!
Glad to hear you're OK, Traveler, and big respect for your commitment to finding the ultimate tripping spot!
How fantastic to live in a country where this is the kind of attitude and treatment afforded to drug overdoses.
 
Interesting experience, to say the least. I'm glad it turned up well, and really props to your wife for handling it that well, it sounds like she had a much worse time than you did!
I'm happy to hear that medical assistance is so good and reasonable there, here it would have gone down very differently, even for a suicide attempt you will most likely be basically mistreated and shamed.

Were you at physical risk at any point (e.g. respiratory depression), or was it "just" loss of consciousness?

And sounds like the use of this substance would be better approached as infrequent, right? Much like ketamine.
 
Wow...not much to say here but to express gratitude to you for being the passionate psychonaut you are, and to your close circle of people who took such good care of you. I had never heard of O-PCE until now, but I'm definitely very interested in trying it, considering Ketamine is one of my all-time favorite substances. This seems like Ketamine on steroids.

Thank you for sharing your journey with us <3
 
Thanks for sharing, and glad that you're okay.
I bow down to the people of the Netherlands. Where else could one be treated that way?
Your culture was most likely a big influence on your sane approach to inner exploration.
Good to know that a heavy experience can also be experienced this way.
May you live a long and healthy life. All the best to you and your close ones <3šŸ™
 
This is a bit of an offtopic, but I'm very curious about your experiences with Moxy. Is there a thread where you tell about these? I couldn't find it.

I've been sitting on a decent amount of this substance since 2020 or so, but never tried it (yet :p). I've always "chickened out" and did an already tried and tested psychedelic instead. But I'd love to try this one at some point.
 
This is a bit of an offtopic, but I'm very curious about your experiences with Moxy. Is there a thread where you tell about these? I couldn't find it.

I've been sitting on a decent amount of this substance since 2020 or so, but never tried it (yet :p). I've always "chickened out" and did an already tried and tested psychedelic instead. But I'd love to try this one at some point.
Same, would love to hear about your extensive experience, @The Traveler. I've gathered that if you're compatible with the substance, there's none that are more euphoric.
 
Interesting experience, to say the least. I'm glad it turned up well, and really props to your wife for handling it that well, it sounds like she had a much worse time than you did!
Yes, for my wife this was a true trauma, and I feel very sorry for her that she had to go through all this, due to my selfish recklessness.

Were you at physical risk at any point (e.g. respiratory depression), or was it "just" loss of consciousness?
When my wife was on the phone with the emergency services they got through all the protocols, and my wife, just like me, has a certificate for full first responder. She stayed extremely calm and professional at all times during this ordeal. The only new 'best practice' that we learned, together with the hospital staff, is that giving me some water to drink was the only thing that should not have been done. This due to possibility activating any extra substance I might still have in my stomach (I took the substance orally in a capsule).

O-PCE, just like ketamine, does not suppress the respiratory system. In the end it was concluded that I was never in any danger of dying. Putting me on my side made sure, that in the case I would vomit, I would not suffocate from it.

And sounds like the use of this substance would be better approached as infrequent, right? Much like ketamine.
Indeed, even though you take much less of it than ketamine (about 6 times less), it's best to either take this only once every few months, or have a regular bladder test to check if no permanent damage will be done to it.

As for tolerance, I noticed that after one week there was no noticeable tolerance left. There is tolerance if you take it again the next day. My guesstimate is that next day you have to take about 1.5 times the amount to have the same effect, though in reality, none should take this substance that regularly.

Thank you for your solid and practical questions!


Kind regards,

The Traveler
 
This is a bit of an offtopic, but I'm very curious about your experiences with Moxy. Is there a thread where you tell about these? I couldn't find it.

I've been sitting on a decent amount of this substance since 2020 or so, but never tried it (yet :p). I've always "chickened out" and did an already tried and tested psychedelic instead. But I'd love to try this one at some point.
When I've some extra time again, I'll make an extensive topic about it, including how you should dose it correctly (stacked in low 5mg dosages, each separated by half an hour, then go to about 15-20mg total depending on your experience with it, never go full in with a full starting dose on Moxy).

I really like Moxy, and will also explain why in that topic once I'll create it.


Kind regards,

The Traveler
 
Wow, what an enormous experience. I can imagine that you, your wife, and your brother must have been incredibly shocked. It’s not a small thing to see a loved one so helpless.

At the same time, what stands out to me most in your message is the safe, warm environment where you felt so secure. I can really relate to how the hospital felt like a comforting, safe place and I hope that one day, one could sign up for a timeslot or something like that, where, under the guidance of a nurse and maybe an attending doctor, all your vitals being monitored, you could explore in an environment that is extremely safe, and go further than what is usual.

It sometimes feels like a loss in our society, that we aren’t able to create those kinds of safe spaces, and I don’t think we’ll really experience that in our lifetime.

But still, that’s something I find deeply recognizable, about your observations.


I still have a chunk of O-PCE, and I can feel its pulse, not to far in future I will jump in too and see if it’s in my top three.

Take care
 
Isn't it weird how some NMDA antagonists can be so much more psychedelic than others?
I think the main difference between most of the arylcyclohexylamines is that some of them are also serotonin reuptake inhibitors.

I'm not sure if there is a link between this mechanism and the increased psychedelic effects, but it would explain the case where someone died on a combo of this substance and venlavaxine. Maybe other cases as well, because any combo that includes an MAOI, or any typical empathogen, or maybe even moxy or 5-MeO-DMT could be very dangerous or at least quite risky if O-PCE is indeed an SRI.

I have no experience with MXE, but i found DMXE much more psychedelic than ketamine, FDCK, DCK or other substances in this categorie, and i suppose it is an SRI too, because MXE is, and that's supposedly very simmilar to it.

One of the craziest psychedelic experiences i've ever had was holing on DMXE while tripping on acid and edibles. I also found it much easier to get a hole experience on DMXE than on any other substance of this class.
This story makes me quite interested in O-PCE as well.

In any case, i can understand it may seem tempting to you to try an O-PCE/moxy combo. But that's probably not worth the risk.
 
Nice report of a novel substace and what happens when pushed too far...fortunately it worked out ok, much to explore.

I did have to chuckle at this part though

Quickly after that a complete team of medical personnel arrived, and after that they took a blood sample to check what substance I could have taken, and send that to the lab. In the meantime, my wife told the medical staff about my work with entheogens, the DMT-Nexus, the science and the harm reductions responsibilities coming with it, and the reason why I take this journeys: so I can provide you with information on what to do and especially what NOT to do (yeah, great job Trav!), This however made a profound change in the mindset of the leading doctor, and he strictly ordered that I would be treated with utmost respect, and that they had to be very gentle with me, and keep score of lots of data to work with me later on.

If only this could be used as a convenient excuse for if we ever got caught with psychedelic use - since we are all probing altered states of mind with these tools and experimenting with combining them with different practices and in different contexts and adding to the collective experiential database, many of us directly involved in research, therapuetic or philosophical use. Yet somehow I dont think every medical or other professional would be so understanding...fortunately it looks like you got sent to the right place.
 
Isn't it weird how some NMDA antagonists can be so much more psychedelic than others?
I think the main difference between most of the arylcyclohexylamines is that some of them are also serotonin reuptake inhibitors.

I'm not sure if there is a link between this mechanism and the increased psychedelic effects, but it would explain the case where someone died on a combo of this substance and venlavaxine. Maybe other cases as well, because any combo that includes an MAOI, or any typical empathogen, or maybe even moxy or 5-MeO-DMT could be very dangerous or at least quite risky if O-PCE is indeed an SRI.
In the case of death by O-PCE combined with venlavaxine, the following was pretty much the conclusion:

"Cause of death was attributed to polyintoxication, with cardiovascular collapse and/or seizure suspected.

The combination likely synergized neurotoxic and cardiotoxic effects."

O-PCE is not considered to be a SRI, though it might interact in a currently unknown indirect way. Venlavaxine however is known for its QT prolongation and O-PCE might have caused compounding cardiovascular stress, with this combination possibly resulting in the fatality.

In any case, i can understand it may seem tempting to you to try an O-PCE/moxy combo. But that's probably not worth the risk.
Combining O-PCE with Moxy might indeed be very risky. Many times moxy gave me the impression that it indirectly involved SERT and GABA.

Best practice in this case would be to avoid these combinations for now, until we get more insights into the interactions of these substances.


Kind regards,

The Traveler
 
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Yet somehow I dont think every medical or other professional would be so understanding...fortunately it looks like you got sent to the right place.
You are absolutely correct on this one.

I was extremely lucky to be handled by a professional doctor, who after talking with my wife, truly understood that this experience would set in motion an improved harm reduction protocol, for this kind of substances, on the internet, for all people, to learn, share and expand.

This topic, with my very personal anecdote, is a statement on how to approach O-PCE, and other strong dissociatives, in a more safe way, that can hopefully reduce hospital visits, while at the same time create wonderfully new and interesting journeys.


Kind regards,

The Traveler
 
When I've some extra time again, I'll make an extensive topic about it, including how you should dose it correctly (stacked in low 5mg dosages, each separated by half an hour, then go to about 15-20mg total depending on your experience with it, never go full in with a full starting dose on Moxy).

I really like Moxy, and will also explain why in that topic once I'll create it.


Kind regards,

The Traveler
I definitely don't want to be both a beggar and a chooser, but I was hoping to nudge this idea back top-of-mind, just in case you forgot. An info dump from someone with so much experience using 5-MeO-MiPT would be amazing.
 
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