I think if you've done extensive research, feel comfortable in experiencing the unknown, and most importantly; have DMT in front of you, then you're as ready as you'll ever get.

DMT is nothing to fear, especially for your first time. In my experience and most reports I've read, the harsher experiences come later if at all, with the beginning full of amazement. My early DMT experiences did not remind me much of mushrooms at all; however since experiencing DMT, my mushroom experiences remind me a lot of DMT! Weird lol but this is a common experience from what I understand.