So SWIY was a regular user of MDMA then? Why does he not show these same signs of tollerance towards Mescaline? And if MDMA had been responsible for damage at the 5-HT2A site, then wouldnt other psychedlics also show the same sort of tollerance as with Mescaline?

SWIM also used MDMA quite heavily in his youth, but still fly's off very small amounts of psilocybin and other psych's that are active at the 5-HT2A receptor. SWIM hasnt tried mescaline yet tho.