I find noopept no short of amazing and agrees with all positive reports in this thread. It is by far the best nootropic I have encountered (out of maybe 20 different). I can add that It REALLY helps me with THC induced brain fog.

I find less being more with noopept and have settled for less than the recommended 10mg. This being said I don't think it's super dose sensitive and after getting an idea on how big a pile 10mg of noopept is I just take a tiny lump on the tip of a knife and drop in my mouth. I almost like the taste now

There are acute effects and effects that build over 3 weeks.

There is an obvious synergy with other stimulants.

After being a VERY dedicated coffee drinker I quit after a month on noopept. The comedowns and jitter when enhanced by noopept is just too much and I now successfully combine it with Guayusa (or if not at home green tea instead). These does not cause the negative side effects of coffee in me. Two friend on methylphanidate has cut their metyhlpenidate doses in half.

For synergy with weed, I find that I don't feel as stoned and guess that this is because I feel less impaired. Memory works better and thereby speech and many other higher functions.

For the downsides of noopept it is a bit beyond my knowledge of brain chemistry but there are some talk regarding noopept increasing brain-derived neurotrophic factor (BDNF) leading to down-regulation of Trk proteins, apparently leading to one getting more stupid instead of smarter. If someone understands these things I'd sure be interested to hear their take on it. It's discussed here: [MEDIA=reddit]Nootropics/comments/189ybm/we_really_need_to_know_about_any_possibility_of[/MEDIA]