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Okay guys, Yuremamine - Whats the score?

Migrated topic.
shoe

shoe

Rising Star
OG Pioneer
read this Yuremamine - Wikipedia this morning,
and was quite shocked to see the last sentance note that yuremamine
has not been extracted by home extractors.

SWIM doesn't think "jungle spice" is particularly different from other dmt pulls, just fattier. Or atleast, his xylene pulls never seemed much different in psychoactive effects. SWIM doesn't think it contains yuremamine; probably just reaching that harder-to-get dmt.

It is interesting to me though that yuremamine might act as a prodrug, and I can see the DMT structure contained within. Very cool pharmacology.

Mah questions To Youuuu...
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Jungle spice - Is it yuremamine?

Yuremamine, can It be extracted with hexane or heptane?

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> Jungle spice - Is it yuremamine?

Probably a mixture of DMT and betacarbolines if you ask me. And the red dye of course...

> Yuremamine, can It be extracted with hexane or heptane?

I'd say no. Looks too polar with all those hydroxyl groups.
 
SWIM Is about to test out jorkest's claims that d-limonene pulls an awesome alkaloid profile. ordered 500ml recently and is about to test it out.
 
soulfood said:
Has anyone used DCM to pull from mimosa? I'd be interested in seeing what that stuff pulls out. So much in that there MHRB.
Click to expand...
ILPT used DCM when doing STB with mimosa(not a good idea.. DCM gettin trapped in mimosa soup...also emulsions form a lot)Yield was low and some lye contaminated product(a bit rough)
Resulting spice smelled very spicey and was strong as hell
 
Yuremamine isn't the jungle spice. Jungle spice is a tryptoline, wich is a beta-carboline.
69ron mentioned in one of the jungle-threads, that he extracted the stuff from chaliponga as well.

Yuremamine is a prodrug for DMT, but it's instable and get's destroyed by heat. That's why it can't be the jungle-spice.

Mimosa is a plant that's just incredibly rich in alkaloids.
 
Its said that yuremamine enables mimosa hostillis root bark brew to be active without an MAOI.

Ive heard reports of mimosa hostillis root bark being brewed alone and producing psychedelic effects, yet analysis of M. Hostillis confirms that there are in fact no ß-carboline or harmala like alkaloids present .

Can anyone confirm that mimosa hostillis root bark brewed alone is psychoactive?

If in fact a mimosa hostillis root bark brew is psychedelic I'm wondering how this is pharmocologically possible as MAO enzymes should destroy the DMT in the alimentary canal.

I have not researched yuremamine in any depth, but I have heard people claim that its the cause for mimosa hostillis root bark brews activity, if this is the case I would be very interested in the pharmocological properties of yuremamine, specially in the interactions between yuremamine and N,N-dimethyltryptamine.

If anything ive said is not correct please correct me, and if anybody can direct me towards a good source of information regaurding yurenamine and its pharmocological actions, specifically its pharmocology in combination with DMT it would be much appreciated as I have been having trouble finding any in depth information on this particular subject.

Thank you.
 

Erowid.org: Erowid Reference 7517 : Isolation and characterization of yuremamine, a new phytoindole : Vepsäläinen JJ, Auriola S, Tukiainen M, Ropponen N, Callaway JC

The Index page for the reference article: Vepsäläinen JJ, Auriola S, Tukiainen M, Ropponen N, Callaway JC Isolation and characterization of yuremamine, a new phytoindole Planta Med 2005 71(11):1053-7
www.erowid.org

AFAIK thats the only paper ever posted on yuremamine, and it contains the speculation on how it might be what's responsible for mimosa cold brew activity without MAOIs due to it's structure.

This is one of our projects for the near future here at the Nexus, to (hopefully) isolate yuremamine through column chromatography and bioassay it, see what we can find out.
 
Thank you for the response!

It would be amazing if someone could isolate and bioassay yuremamine, I would be specially interested in the pharmocological action between yureamine and Dimethyltryptamine, or even yuremamine and mono-amine oxidase .

Ill keep an eye out for any information regaurding yuremamine, in the mean time please keep me posted as the information comes in.

Thank you.
 
I noticed a BIG difference between the dark Brown mimosa extract (only some of it was DARK, it FELT dark too) and what ACRB yields. I had no chromatography multi dish spectrometer available so I will shut up about it.

IMO from what I smoked this is an important topic.





"Further up and Further In"
Aslan
 
Looking at the structure of Yuremamine, I consider it quite a stretch to say that it will break down into DMT, or acts like a prodrug to DMT. It's kinda like saying that LSD is a prodrug for DMT, as both chemicals contain the structure of DMT within them. That indole nitrogen is most definitely occupied, and so is its immediate carbon neighbor. Also, the way those phenols are attached looks like it might just rip right off but the way those bonds are drawn is representative of chirality (I may be wrong...but those are just plain carbon-carbon bonds).

Anyway, I think this molecule is its own thing and should not be regarded as a prodrug for DMT.
 
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