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On the physiological role of DMT

Migrated topic.
E

efrecska

Rising Star
Here is something fresh:
www.plosone.org

Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and cell survival, and mediates anti-inflammatory responses and immunosuppression in murine in vivo...
www.plosone.org www.plosone.org
FrEd
 
Awesome! I think your work is really interesting. I've read through most of the paper you just posted and am working my way through your most recent work. I have been studying tumor-associated-macrophages (TAMS) and specifically their role in glioblastoma as promoters of angiogenesis. TAMS are often classified as a hyperpolarized M2 macrophage phenotype, with overactive immunosuppressive effects and uncontrolled angiogenesis. I have been curious as to what effect sigma receptor agonism might have on their phenotype, cytokine production, and migration. Considering the preferential, active uptake of DMT into the brain, it seems like a good candidate for affecting the brain's resident microglia. It is interesting to me to see the increase in NK cells following ayahuasca, and yet the reduction of pro-inflammatory cytokines also.
Forgive my ignorance in my speculations.. I am an undergrad, still learning my immunology. I wanted to ask your thoughts and speculations though on the subject.

Great work!
 
Yet another DMT related study & article about the possible benefits & implications from PLOS ONE

It's pretty dense so I'll attach the article and for those impatient, here is the conclusion:

"We conclude that the function of dimethyltryptamines may
extend the central nervous system activity and may play a more
universal role in immune regulation. Here we demonstrate for the
first time that NN-DMT and 5-MeO-DMT have potent
immunomodulatory effects on the functional activities of human
dendritic cells operating through the sigma-1 receptor. We also
show that DMT-mediated sigmar-1 activation can interfere with
both innate and adaptive immune responses. On the one hand, it
strongly decreases the levels of pro-inflammatory cytokines and
chemokines such as IL-1b, IL-6, TNFa and IL8, while upregulates
the production of the anti-inflammatory cytokine IL-10. On the
other hand, NN-DMT and 5-MeO-DMT pre-treatment of
pathogen-activated moDCs abolishes their capacity to initiate
adaptive immune responses mediated by inflammatory Th1 and
Th17 cells. These findings greatly expand the biological role of
dimethyltryptamines, which may act not only as neuromodulators
or psychedelics, but also as important regulators of both innate
and adaptive immunity. Thus, the DMT-sigmar-1 axis emerges as
a promising candidate for novel pharmacotherapies of chronic
inflammatory and autoimmune diseases."
 

Attachments

  • Szabo_A_et_al_2014_PLoS_ONE-libre.pdf
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cave paintings said:
: "Considering the preferential, active uptake of DMT into the brain, it seems like a good candidate for affecting the brain's resident microglia."
Yes! Good idea. The brain tissue cann't handle inflammation the same way peripheral tissues can. DMT can be a protective factor in keeeping inflammatory responses at bay.
FrEd
Click to expand...
 
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