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Piperine: The opener ?

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rOm

rOm

Rising Star
OG Pioneer
This alcaloid from black pepper is really easy to extract.
Plus it allows certain entheogen to manifest more vividly without the higher dosage in which side-effect manifest.
Recently found the low dose iboga rootbark: 1 gram to work like a 3 grams doses.
Now 500mg yohimbe is noticably psychoactive with zooming and such visual effects....

Unless it is reverse tolerance from iboga this piperine looks promising.
 
Uh, have you never heard of harmalas? (harmine, harmaline and THH) I advise you to buy some syrian rue seeds. Harmalas are better that piperine.
 
Seraph, harmalas are used extensively. But they are quite psychoactive on their own.
though piperine isn't noticable, you may try eat some strong turmeric dish or somethingelse and you'll see for yourself.
Plus, I try not to mix harmalas with nearly any herbs there is, like the random trips on erowid.
Some harmalas combos are dangerous (i.e. stimulants).
 
Seraph, I would ask you to consider that rOm has 800 posts while you do not yet have 200.
In that light, your comment seems incredibly condescending to him. Perhaps his explaination of experiences with piperine are inadequate: in which case, request appriopriate response.
Do not assume, thank you.

rOm: fascinating. i wonder what piperine in combinatino with harmalas woudl be like!
 
shadowman, yeah, actually, I wait to try pharma with piperine and curcumin.
I already did iboga 1 gram only and piperine and curcumin, it was lovely.
stronger than the two grams RB without it for sure.
The two grams Iboga RB with harmalas (which I'm not sure is a safe thing) was however stronger experience than all the above.
I'm going slowly but surely to experiment piperine with other entheogens.
 
yea Piperine is an amazing substance indeed. Also potentiates the effects of many fruits and vegetables, thus resulting in higher nutritional intake value.

Does anyone know how Piperine interacts with Piracetam and choline bitartrate? Does it potentiate them as well, or would it result in an adverse reaction? Does anyone have direct experience with this? Thanks:d
 
Load your dinner with tons of freshly ground pepper, cook some cayenne into the dish, also cook some fresh turmeric root, or powder, into the dish. These three delicious spices when combined create such a blissful trancey relaxed state every time I consume them. I try to put them in everything I eat where the ingredients fit.
 
phantastica, it depends on what enzymes they are metabolized by. black pepper inhibits CYP1A2, CYP3A4, and CYP2D6. This can be good or bad depending on the substance your supplementing it with.
 
Shadowman-X, I extract it with a IPA long soak (days).
Filter and save liquid (black if black pepper is used).
Bombed with water until no more clouding forming.
Few days later collect crystals through filter and evaporate.

N'joy
 
PsilocybeChild said:
phantastica, it depends on what enzymes they are metabolized by. black pepper inhibits CYP1A2, CYP3A4, and CYP2D6. This can be good or bad depending on the substance your supplementing it with.
Click to expand...
ok i see, thanks for letting me know about the concept behind the mechanism of action. I tried to find the metabolic processes involved in the metabolism of Piracetam, but couldn't find information regarding it; so idk what enzymes are involved.
Since piracetam has been proven to be very safe even at large doses, I'll just combine the piperine with it, and some choline and see how it goes. Thanks for the info PsilocybeChild!:d
 
Anyone have any experience of using piperine with mescaline?

That's probably the substance I like to stretch further than any other because preparing enough materials for a high dose mescaline trip can be quite expensive.
 
Hmmm using the above IPA soak method i never manage to capture "floating crystals" on filter but i tend to have heavy precipitate. That looks more crystaline than the resin and if dissolved in the minimum amount of hot acetone i have crystaline precipitation :).

Something i have also tried and it seems to work: I first add some hot (even boiling) water in the warmed up piperine/resin IPA solution (small volume 20-30 ml) and follow it with more hot water that has sodium bicarbonate it. It seems to keep more "gunk" in the water. The resulting precipitate looks more crystaline and the water looks dirtier.

The reason for adding the small amount of pure hot water first is to keep sodium bicarbonate from precipitating. Stiring while adding helps also a great deal.

Also keep in mind that the CYP450 inhibition activity of piperine is not the only interesting activity of it. For example i find its activity to inhibit p-glycoproteins more interesting.
 
soulfood said:
Anyone have any experience of using piperine with mescaline?

That's probably the substance I like to stretch further than any other because preparing enough materials for a high dose mescaline trip can be quite expensive.
Click to expand...

I've tried with 200mg unwashed mescaline (pure mescaline unknown).
I had a strong come up and then a strong stimulation. I didn't notice an increase in visuals however or synsethesia which is what I'm looking for.
The experience will need to be repeated.
 
Also another thing to note: Its best if piperine is not exposed to light, it is known to isomerize in chavicine -its biological activity? I do not know much of it but i tend to keep piperine during extraction in dark cupboards.
 
usually take anything between 20 to 40 mg most of the time with curcumin oil tincture 1/2 an hour before dosing. less tolerance were noticed with some compounds.
and yes, you're right its best to avoid light (sunlight?) for a best conservation.
 
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