Possible use of harmalas in place of Rizatriptan

[JP]

First, I am aware of Rizatriptans negative interaction with MAOI’s.

My mother is a long time sufferer of migraines. I recently looked into the medication she takes for it, Rizatriptan which is essentially dmt, in chemical structure. Reading into the pharmacology I discovered it is a 5-HT 1A agonist, she also describes very similar side effects as I get from harmalas. I was wondering if anyone here has heard of or had any success treating migraines with harmala alkaloids? She is usually hospitalized for one week a year because her liver becomes swollen, most likely from eating ibuprofen like an drug addict. I would very much like to get her off ibuprofen and Rizatriptan, being replaced by CBD and possibly harmalas.

 

[Ulim]

LSD is the one for headaches.
Afterall that was the main use of ergot alkaloids before tripping

 

[urtica]

Yea, maybe check out cluster busters?

Clusterbusters - The Cluster Headache Advocacy Group

We support research for better treatments and a cure while advocating to improve the lives of those struggling with cluster headaches.

clusterbusters.org

I realize that cluster headaches are not migraines but there is probably some good material there.

 

[justb612]

So many people report having 70% of their migraines gone after just 3 days in nutritional ketosis, maybe try the ketogenic diet?


Also sorry for not actually replying to your question :/ i have no idea

 

[melotikaci]

So many people report having 70% of their migraines gone after just 3 days in nutritional ketosis, maybe try the ketogenic diet?

I second that.

Check this out for more info

 

[null24]

What about psilocybin? Isn't that what people are using to mitigate migraines?