Potentiation of 5-MeO-DMT-induced hyperthermia by harmaline

[cave paintings]

Published Feb. 2015.
If of interest to anyone wanting to understand 5HT receptor pharmacology, and thermal changes in serotonin syndrome. I actually came across this paper coincidentally as I was looking over publications for a prospective graduate school lab.

Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors - PubMed

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and harmaline are serotonin (5-HT) analogs often abused together, which alters thermoregulation that may indicate the severity of serotonin toxicity. Our recent studies have revealed that co-administration of monoamine oxidase inhibitor harmaline...

www.ncbi.nlm.nih.gov

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[endlessness]

Thanks for sharing!

A few things that caught my attention:

They make no distinction between 'use' and 'abuse' (in fact, they only use the word 'abuse').

The dosages are also very high. The experiment was with mice, but anyways the smallest 5-MeO-DMT dose was 2mg/kg, that would be 140mg for a 70kg person, which is absurdly high.

Also I don't understand how even giving 0, or in other words, nothing, induced a measurable change of over 1 degree celcius in mice temperature.

I wonder what kind of body temperature changes are seen with humans, if it's anything close to that and if it's in any way dangerous.

Maybe someone with more knowledge in the area can give more extended feedback on this publication.