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Previously Undescribed alkaloids and anti-tumor activity of P. Harmala

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Woolmer

Woolmer

Established member

While the paper is rather focused on the anti-tumour capabilities of P. Harmala with indeed very interesting results, it also lists 6 undescribed alkaloids of P. harmala, as well as 6 alkaloids that were not known to occur in the genus of peganum. To note they used aerial parts of the plant.

In our previous investigation on the seeds and roots of P. harmala, a series of antitumor alkaloids with novel scaffolds such as pegaharmines A-D, peganumine A, and pegaharmols A-B were found (Wang et al., 2016, 2017; Li et al., 2020). HPLC analysis on the total alkaloids from the aerial parts, seeds and roots of P. harmala revealed the presence of different constituents. Thus, our investigation on the alkaloids of the aerial parts of P. harmala led to the isolation of 20 compounds including six previously undescribed ones.
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Good finding!
I don't understand much of the paper, but I really hope that it leads to further studies of this fascinating plant.
Thank you.
 
The aerial parts are very active. It was too strong and serious for me and I couldn't get myself to try drinking light on top of it. The seeds appear recreational in comparison... Thank you for sharing.
 
Interesting account dithyramb.

Would be curious to hear more accounts, as the aerial alkaloids are clearly different to the seeds.

By analyzing the structural characteristics of all the separated products, the main alkaloids from the aerial parts of P. harmala were found to be quinoline- and quinazoline-type, which were significantly different from the alkaloids reported in seeds and roots.
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Yes it is very interesting. Even with such a difference in alkaloids, the visuals were the same as seeds. Triangular patterns and pyramids are a very common theme in my allied strain of rue.
 
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