I was thinking last night, about how certain natural herbs/plants, like lemon oil and caocao have uses to reduce bodyload and vasoconstriction with certain compounds. Vasoconstriction is definitely an issue with me, especially with phenethylamines. I feel like some cacoa for vasodialiation, lemon essential oil for 5-ht3 antagonsism/nausea control, and a low dose propanolol could all be useful and effective techniques to counteract some of the uncomfortableness caused by unwanted 5-htx receptor agonism, most notably 5ht3 for nausea, and 5htb for cardiovascular affects. This is all relative to the binding profiles of the compounds in question however, and not all phens or trypts may require all (or any) of the above techniques. As well, caution must be taken when combining these compounds and must be done so in low doses at first to gauge interactions. Basically, we're gonna have to shulgin it. :lol:
It will be cool though, if eventually there could be a special mix you could take, to reduce or eliminate the body-load or uncomfortableness associated with some psychedelics. Custom tuned to block certain receptors or interact with them on some level, reducing the negative affects caused by the drug you are taking doing something to that particular receptor. Lot of fine tuning would be required though. Also, if a certain combo makes you less aware of the negative body-load, but its affects are still present, this could become dangerous with higher doses where one would usually not go, except for the reduction in body-load. Kind of like if you are taking a psychedelic PEA, that exhibits stimulating affects, but you take something that makes it seem less stimulating. But it still exhibits stress on your heart/cardiovascular system. That would be a dangerous scenario where it wouldn't feel dangerous, but certainly is.
As well, some people don't necessarily think nausea associated with serotonegenics is a bad thing, and has a use. I've heard someone on a forum somewhere taking about the cactus purge. They said something along the lines of that purge has to send a hit of something to the brain for sure. Perhaps this is a useful element of the drug itself, and being that serotonin/its receptors in the gut are partly responsible for mediating vomiting/diarrhea, i tend to agree.
But for some compounds there are negative body affects that are just that to some people, and reducing them could greatly increase the overall usefulness of a compound imho.
BTW- i tried this with a low 80mg dose of mescaline, 10mg of propanolol that is, and it seemed to help with the albeit slight body load present. But really 80mg of mescaline presents very little body load anyway, it was just to make sure a low dose would present little/no interactions.
