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Psilocybin to extend life - study

Here’s the full study: Psilocybin treatment extends cellular lifespan and improves survival of aged mice - npj Aging

Mice received a low-dose (5 mg/kg) initially for the first treatment to acclimate mice for long-term treatment, followed by monthly high-dose of psilocybin (15 mg/kg in sterile saline) or vehicle (sterile saline) via oral gavage (on conscious mice) once/month (10 treatments total)
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The low starter dose of 5 mg/kg of psilocybin for a mouse is equivalent to a 24.4 mg dose for a 60 kg human. That’s roughly 2.44 grams of dried mushrooms assuming a combined 1% psilocybin and psilocin content.

A 12.3 adjustment factor was used to calculate the human equivalent dose, per online articles such as this one: How to estimate human equivalent doses from animal studies

According to the scaling factors in the table above, to convert a dose in mg/kg body weight to a human equivalent dose in mg/kg body weight, one needs to use a scaling factor of 12.3. This means that a dose of 12.3 mg/kg body weight for a mouse would be equivalent to a dose of 1 mg/kg body weight for a human being. In other words, a human needs 12.3-times lower dose on a body weight basis, to get the same effect as the mouse.
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The 15 mg/kg monthly dose for the mice would be equivalent to 7.3 grams of dried mushrooms. That’s a heroic dose every month. The 15 mg/kg was selected by the researchers to account for the shorter half-life of psilocybin in humans versus mice:

However, mice exhibit a significantly faster metabolic profile for psilocybin compared to humans, leading to a shorter half-life and more rapid systemic clearance of psilocin; the elimination half-life of psilocin is ~0.9 h in mice33 vs 1.8–3 h in humans34. Due to this rapid clearance in mice, a higher dose of 15 mg/kg was selected to ensure sufficient systemic exposure comparable to those observed in human clinical trials. It is also important to note that toxicology studies indicate that psilocybin is well tolerated in mice up to doses of 180–250 mg/kg35, which is well above the dose utilized in this study.
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On the other hand, the conversion article says a less conservative conversion factor would be 7.27:

Using the above scaling factors, a 7.27 mg/kg body weight dose for a mouse would be equivalent to about 1 mg/kg body weight for a 70 kg adult human.
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So, if we adjust dosage down to account for longer half-life in humans and adjust up for the less conservative equivalence factor, we still end up with a 6-7 gram journey per month.
 
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They're repeating this stuff from the '70s 😁 and putting new people's name on it that have not died. 😎
People knew this for a long time, if they knew much about mushrooms or tripping but the mainstream of course didn't.
What can I say? This will probably be the last round of people that get to take other people's work and get paid for it, because they actually will pill it this time - we will see?

To the topic I think that the different ones have different chemical profiles and that the strongest ones may be the ones that give the best medical effects. Or at least best effects with less body load.
 
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