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RC of the X-XAPBX class

Migrated topic.

Ulim

Rising Star
So you all probably know the difference between MDXX compounds and Bath Salts like 4-MMC and Methylone (Cathinone class stimulants)

But those arent the only compounds out there that are supposed to mimic the effects of MDXX compounds. Another class are the Benzofuran derivatives
uW9Y2Sk.png

As you can see they are structually very similar to MDXX but they are missing one oxygen.
They are the Furan
substituted Phenethylamines.
Furan_chemical_structure.png

This is the furan molecule ^
MDXX compounds are Methylenedioxy substituted phenethylamines.
200px-Methylenedioxy_skeletal.svg.png

Methylenedioxy group^

6-APB also known as "Benzofury" was one of the first to be synthesised and used commonly.
It was initially discovered by David E. Nichols as an alternative to MDMA for medical treatment because MDMA is well known to be neurotoxic.

It is disputed wether 6-APB is safer than MDMA as it still shows the same effects and other forms of toxicity like cardiotoxicity because it affects the same receptors in pretty much the same way.

What is dangerous about those substances is that they are in many cases 90-150% as strong compared to MDMA. Which can make it easier to be overstimulated especially if there is combined use with other stimulants like caffeine and amphetamines.

Now you may ask whats the problem here? "I can just test my stuff with marquis and then i know!"
The problem is that compounds of the X-XAPBX class are so similar to MDXX compounds that they often react the same way with test reagents.
You cant tell if its MDMA or 6-APB with Marquis alone. And even multiple tests will not always give a satisfying result that you are indeed taking MDMA or MDA and not some X-XAPB because of different salts like succinates, HCL, fumarate or more. Even the slightest difference will change the hue enough that you can only tell them apart if you have a true MDXX sample to test on the side for a direct comparison
One very bad and unreliable way to tell X-XAPB is from the smell because of different precursors:
Because for MDXX safrol can be used there might be some impurites of it left which gives a different smell. But dont forget that MDMA and MDA can be made smell free too.

Now why is all this information important you may ask?
Its important because those drugs are RC that arent well understood and studied yet
They might show similar effects at near similar dose range but you dont know if one of those substitues might have some effect on your body that you will never recover from.

They are relatively rare but compounds like 6-APB is nowaday very common because of their "Legality" in some places in the world.


Im not saying that X-XAPB is as dangerous as cathinones or NBOMES. But you need to thread carefully if you want to be sure of what you take and want to evade the risk of a to strong dose and overstimlation or a dangerous unkown sideffect.

This post is supported by The Traveler he kinda wanted (forced 😁 ) me to do it
 
The Traveler said:
Is there any reliable way to test for this substance, at all?

Some reagents like Hoffman, Ehrlich show slight reactions (brownish) on mulitple of X-XAPBX compounds while MDMA shows none. The problem is that MDMA impurites might also turn brownish.

Simons reagent eliminates most of the X-XAPBX class compounds because it turns blue on MDMA but not on X-XAPBX. [YOUTUBE]

5-MAPB is an outlier here because it reacts blue too. [YOUTUBE]

Also another problem is the sheer amount of X-XAPBX class compounds because of saturated and unsaturated rings. Also its possible to swap the position of the oxygen for even more possibilites.
This makes it hard to collect reaction information of all of them so we might not know if there are some that match MDXX even more closely in their reactions with test reagents.

BTW the naming of the compounds is kinda difficult.
5-XXXX means the oxygen is at the bottom.
6-XXXX means its at the top.
X-XXDX means its unsaturated.
X-0XXX the 0 can be replaced by functional groups that end up at the "tail" methyl ethyl etc. Just like MDMA is the methamphetamine methylenedioxy, 5-MABP is a methamphetamine furan derivative.
 

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It is best to use a combination of TLC and reagent testing.

TLC alone is excellent if you have something to test as a standard, and a bit of knowledge how TLC works.

lets say for example you wanted to see if you had 5-meo-DMT and not 5-meo-NMT, for argument sake. You know that 5-meo-DMT is less polar and rises higher up the plate, but you don't know exactly how high it rises, you only get one spot when you test so you know its not a mixture.

So you test it against DMT. You know DMT is a bit less polar than 5-meo-DMT and it will be a little bit higher on the plate.

You find that the spot of your test is just a few mm below DMT, and now you can be fairly certain its 5-meo-DMT and not 5-meo-NMT!

Here is an example, it is a bit hard to see though: 1st row is a mixture of crude freebase DMT, (top spot is DMT), the middle is the sample im testing, which looks to be nearly pure 5-meo-DMT! and the third row is 5-meo-tryptamine, another control which I was expecting to be lower down the plate as its a primary amine.
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To further this, you can test each spot with a reagent by dropping it on the plate and seeing how it reacts. Additionally, the colour tests are easier to see on a tlc plate because the compound is spread out in a fine uniform layer on a white background.

In the case of MDMA and X-APB, you know APB will rise higher than MDMA on the plate because its less polar with the loss of oxygen in the ring system. and the unsaturated version even more so!

In case you don't have a standard, you can just use caffeine! Even coffee beans will work in TLC! Members here on the nexus put together a great database to test relative distances to caffeine using MeOH:ammonia solvent system (100:1 if im not mistaken, 25% ammonia)

You can find rfs using this calculator : https://chat.dmt-nexus.me/tlc_ratio.aspx

TLC + reagent results are here, and you can see they are more clear colour differences on TLC.
 
Just to clear up a point of terminology/nomenclature:

We have a couple of errors here,
X-XXDX means its unsaturated.
and here,
you know APB will rise higher than MDMA on the plate because its less polar with the loss of oxygen in the ring system. and the unsaturated version even more so!
APDB is saturated in the furan ring; APB is the unsaturated compound. Therefore the APB rises even higher because it is unsaturated and therefore less polar.

[Edited following discussion: seemed to imply that APB was the unsaturated compound.]
 
downwardsfromzero said:
Just to clear up a point of terminology/nomenclature:

We have a couple of errors here,
X-XXDX means its unsaturated.
and here,
you know APB will rise higher than MDMA on the plate because its less polar with the loss of oxygen in the ring system. and the unsaturated version even more so!
APDB is saturated in the furan ring; APB is the unsaturated compound. Therefore the APDB rises even higher because it is saturated and therefore less polar.


Sorry I don't know the terminologies on the APX compounds.

In this case, the unsaturated 'furan' is indeed less polar than the saturated hydrofuran... it delocalizes electrons on the oxygen.. especially in this case as they can distribute through the phenyl, the fully aromatic version is very nonpolar
 
Thanks for getting back. Ok, so the unsaturated one is less polar, and your reasoning for that seems plausible.

Pubchem lists the calculated XLogP3 for the 5- and 6-(2-aminopropyl)benzofurans as 2.1, whereas the value for the corresponding dihydro compounds is 1.7. The lower numbers indicate more polar compounds.


All the 'saturated' vs. 'unsaturated' terminology refers to is the double bond in the benzofurans, i.e. 5-APB/6-APB are unsaturated, while 5-APDB/6-APDB, the 2,3-dihydrobenzofurans, are saturated (not counting the benzene ring, of course!)

Hopefully this clears up the ambiguity.
 
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