Researchers unravel the biosynthesis of psilocybin

[Creo]

Janis Fricke, Felix Blei, and Dirk Hoffmeister of Friedrich Schiller University Jena have identified and characterized to the greatest extent so far the four enzymes that the mushrooms use to make psilocybin. The team then developed the first enzymatic synthesis of the compound, setting the stage for its possible commercial production (Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201705489).

‘Magic mushroom’ enzyme mystery solved

cen.acs.org

 

[obliguhl]

With that knowledge in hand, the team designed a one-pot reaction using three of the enzymes to prepare psilocybin from 4-hydroxy-L-tryptophan.

So that means you'd throw three enzymes + 4-htp together and it would essentially brew a psychedelic? Wow!

 

[Psilociraptor]

Hey now this fits right in with the thread on Crispr/Cas9 for producing psychedelics

For those interested in the actual study http://sci-hub.cc/10.1002/anie.201705489