Unfortunately...the Caapi is a monoamine oxidase inhibitor which can produce a lethal rise in your blood pressure if you are on serotonin re-uptake blocking drugs like Lexapro. The combo can potentially give you a stroke or a bleed inside your brain or shut your kidneys down. Bad combo.  DMT alone...is another story. SWIM takes a similar ssri...and has started smoking dmt without problems. Avoid the ayahuasca...