Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
Normal
I went ahead and got some hydroxypropyl-beta cyclodextrin (HPBCD) which is referenced in the salvia patent and the original Nexus thread mentioned above. The idea was to try to make salvia crystal bioavailabe in a HPBCD solution.Procedure:1- Homegrown salvia was given thanks, and after requesting permission, harvested. The plant material was dried and subsequently extracted with very cold acetone 3x. Cold acetone was allowed to settle and a small solid residue decanted. After evaporation, 100mg of fluffy slightly green shiny beautiful crystals where collected. The green hue indicated the crystals we're not completely pure. Material was bioassayed by smoking 1mg resulting in strongly leaving this reality and exploring an interesting new place where the 3rd dimension was missing and myself and all the people I know did not exist in any form of memory. I estimate that the final extract material contained at least 50% salvinorin A, but cannot be sure.2 - Several HPBCD/Water/Ethanol solutions we're tested by keeping them in the mouth for 20 minutes. After using 80mg of extract im total I can report that there were no positive significant results. The best results were obtained at 5ml 75% ethanol, 20% HPBCD and 15mg extract, but the burning sensation was very unpleasant. I cannot even say that HPBCD helped absorb the extract because the burning was so unpleasant that I did not test a control with 0% HPBCD. At lower ethanol content (40%, 5%, and 0% where tested) results were poor.In conclusion it does not seem that HPBCD is a practical way to make salvia extract buccally active in water/ethanol solutions. However, the substance has shown very positive results for steroid sublingual bioavailability. I'll move on to testing mushroom tea next. The nexus DMT/HPBCD work is discussed here.
I went ahead and got some hydroxypropyl-beta cyclodextrin (HPBCD) which is referenced in the salvia patent and the original Nexus thread mentioned above. The idea was to try to make salvia crystal bioavailabe in a HPBCD solution.
Procedure:
1- Homegrown salvia was given thanks, and after requesting permission, harvested. The plant material was dried and subsequently extracted with very cold acetone 3x. Cold acetone was allowed to settle and a small solid residue decanted. After evaporation, 100mg of fluffy slightly green shiny beautiful crystals where collected. The green hue indicated the crystals we're not completely pure. Material was bioassayed by smoking 1mg resulting in strongly leaving this reality and exploring an interesting new place where the 3rd dimension was missing and myself and all the people I know did not exist in any form of memory. I estimate that the final extract material contained at least 50% salvinorin A, but cannot be sure.
2 - Several HPBCD/Water/Ethanol solutions we're tested by keeping them in the mouth for 20 minutes. After using 80mg of extract im total I can report that there were no positive significant results. The best results were obtained at 5ml 75% ethanol, 20% HPBCD and 15mg extract, but the burning sensation was very unpleasant. I cannot even say that HPBCD helped absorb the extract because the burning was so unpleasant that I did not test a control with 0% HPBCD. At lower ethanol content (40%, 5%, and 0% where tested) results were poor.
In conclusion it does not seem that HPBCD is a practical way to make salvia extract buccally active in water/ethanol solutions. However, the substance has shown very positive results for steroid sublingual bioavailability. I'll move on to testing mushroom tea next. The nexus DMT/HPBCD work is discussed here.
