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After all the previous fails, I can report that the dried solution is at least in part buccally activel :thumb_up: The salvinorin must have complexed while drying. It was 6ml 75% ethanol, 48mg green powder from a cold acetone salvia extract and 0.5g of HPBTC. The solution was shaken a few times before allowing to dry, and this shaking may or may no matter (aka I don't know, sorry).

The solution was dried on a glass tray for 24 hours. Scraping it up was hard and required some muscle but doable. Based on bioassay it seems like most if not all of the salvia was complexed and is active if the dried residue is held in the mouth for 10 minutes. There is only mild bitterness if any (much more enjoyable and bearable than the quid method imo).

It does seem that drying is essential here to get complexation as others have mentioned before in the links above (thank you). Outside sources suggest spray drying and lower PH for their particular complexation example.

This opens a lot of questions,

Can someone repeat/confirm this? Is shaking before drying needed?
Did all the salvinorin A get complexed? If any did not it will not be absorbed and wasted.
Does this open up new extraction methods (all of a sudden complexed salvinorin is soluble in water, not sure how soluble it is in IPA)
Can the complexation occur while drying the original acetone from the extraction if HPBTC is simply added to it before the first evaporation?
How powerful can the complexed powder be? Naive answer using the Molecular weigh ratio suggests the final product can be ~25% salvinorin with perfect complexation (no excess of HPBCD or loss of salvinorin) and starting with pure product.
A simple water solution can be made with the complexed salvinorin. Is it stable and buccally active? What about orally active, can it be drunk?
Did I complex the ethanol and also create alcohol powder? This is bad since it means there could be salvinorin that cannot find an empty HPBCD ring (ethanol and salvinorin are competing)
Is there a better solvent to complex these?
Is this reversible? Can the salvinorin be uncomplexed for fun or for smoking purposes (or to help answer previous questions)?

Will try to answer these and other questions as they come up over time. Also interested in any help/input.

Thanks for reading.

<blockquote data-quote="Loveall" data-source="post: 3810561" data-attributes="member: 20">After all the previous fails, I can report that the dried solution is at least in part buccally activel :thumb_up:&nbsp; The salvinorin must have complexed while drying. It was 6ml 75% ethanol, 48mg green powder from a cold acetone salvia extract and 0.5g of HPBTC. The solution was shaken a few times before allowing to dry, and this shaking may or may no matter (aka I don&#039;t know, sorry).The solution was dried on a glass tray for 24 hours. Scraping it up was hard and required some muscle but doable. Based on bioassay it seems like most if not all of the salvia was complexed and is active if the dried residue is held in the mouth for 10 minutes. There is only mild bitterness if any (much more enjoyable and bearable than the quid method imo).It does seem that drying is essential here to get complexation as others have mentioned before in the links above (thank you). Outside sources suggest spray drying and lower PH for their particular complexation <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364370/#!po=43.6709" target="_blank">example</a>.This opens a lot of questions,Can someone repeat/confirm this? Is shaking before drying needed?Did all the salvinorin A get complexed? If any did not it will not be absorbed and wasted.Does this open up new extraction methods (all of a sudden complexed salvinorin is soluble in water, not sure how soluble it is in IPA)Can the complexation occur while drying the original acetone from the extraction if HPBTC is simply added to it before the first evaporation?How powerful can the complexed powder be? Naive answer using the Molecular weigh ratio suggests the final product can be ~25% salvinorin with perfect complexation (no excess of HPBCD or loss of salvinorin) and starting with pure product.A simple water solution can be made with the complexed salvinorin. Is it stable and buccally active? What about orally active, can it be drunk?Did I complex the ethanol and also create alcohol powder? This is bad since it means there could be salvinorin that cannot find an empty HPBCD ring (ethanol and salvinorin are competing)Is there a better solvent to complex these?Is this reversible? Can the salvinorin be uncomplexed for fun or for smoking purposes (or to help answer previous questions)?Will try to answer these and other questions as they come up over time. Also interested in any help/input.Thanks for reading.</blockquote>

[QUOTE="Loveall, post: 3810561, member: 20"] After all the previous fails, I can report that the dried solution is at least in part buccally activel :thumb_up: The salvinorin must have complexed while drying. It was 6ml 75% ethanol, 48mg green powder from a cold acetone salvia extract and 0.5g of HPBTC. The solution was shaken a few times before allowing to dry, and this shaking may or may no matter (aka I don't know, sorry). The solution was dried on a glass tray for 24 hours. Scraping it up was hard and required some muscle but doable. Based on bioassay it seems like most if not all of the salvia was complexed and is active if the dried residue is held in the mouth for 10 minutes. There is only mild bitterness if any (much more enjoyable and bearable than the quid method imo). It does seem that drying is essential here to get complexation as others have mentioned before in the links above (thank you). Outside sources suggest spray drying and lower PH for their particular complexation [url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364370/#!po=43.6709]example[/url]. This opens a lot of questions, Can someone repeat/confirm this? Is shaking before drying needed? Did all the salvinorin A get complexed? If any did not it will not be absorbed and wasted. Does this open up new extraction methods (all of a sudden complexed salvinorin is soluble in water, not sure how soluble it is in IPA) Can the complexation occur while drying the original acetone from the extraction if HPBTC is simply added to it before the first evaporation? How powerful can the complexed powder be? Naive answer using the Molecular weigh ratio suggests the final product can be ~25% salvinorin with perfect complexation (no excess of HPBCD or loss of salvinorin) and starting with pure product. A simple water solution can be made with the complexed salvinorin. Is it stable and buccally active? What about orally active, can it be drunk? Did I complex the ethanol and also create alcohol powder? This is bad since it means there could be salvinorin that cannot find an empty HPBCD ring (ethanol and salvinorin are competing) Is there a better solvent to complex these? Is this reversible? Can the salvinorin be uncomplexed for fun or for smoking purposes (or to help answer previous questions)? Will try to answer these and other questions as they come up over time. Also interested in any help/input. Thanks for reading. [/QUOTE]