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I believe I can now answer this particular question. It has been shown when working with testosterone (see attachment) that while ethanol does have affinity for HPBCD, and can compete with the drug in solution by slightly lowering solubility, after a good evaporation no ethanol remains in the HPBCD/Testosterone complex powder. This is consistent with the salvinorin tests above. Preliminary conclusion is that 75% ethanol is a viable cosolvent for Salvinorin/HPBCD complexation, but we still need independent confirmation and repeatability.Edit: Future posts and updates will be done in the original salvinorin complexation thread started in 2012. Mods can consider merging the threads (request submitted).
I believe I can now answer this particular question. It has been shown when working with testosterone (see attachment) that while ethanol does have affinity for HPBCD, and can compete with the drug in solution by slightly lowering solubility, after a good evaporation no ethanol remains in the HPBCD/Testosterone complex powder. This is consistent with the salvinorin tests above. Preliminary conclusion is that 75% ethanol is a viable cosolvent for Salvinorin/HPBCD complexation, but we still need independent confirmation and repeatability.
Edit: Future posts and updates will be done in the original salvinorin complexation thread started in 2012. Mods can consider merging the threads (request submitted).