Just to bring the uninitiated up to speed on some of the concepts.
As it is known cyclodextrin(a,b,y,etc) complexation of molecules can improve bioavialability of some drug molecules via buccal(sublingual) administration. This is the case for certain nitrogen containing compounds such a 25i-NBOMe. A similar methodology has some-what recently been applied to cannabidiol a terpenoid(see attached paper for details).
Normally terpenes and many drug molecules have a hard time crossing into the blood stream by sublingual means. This can be aided by 'enclosing' these molecules in cyclodextrins. Cyclodextrins, or CD's for brevity, are essentially cylindrical sugar polymers. When a molecule is complexed with them the molecule fits inside of them like a ring to a finger.
The CD is the cylindrical shaped molecule.Note this image is not a completely accurate depiction of the goal but it is demonstrative
(Image taken from wikipedia)
The issue with extracted Salvinorin(s) is that they aren't really active sublingually. From personal experimentation I obtained a come-up of a salvia experience lasting maybe 20 seconds, as did a friend of mine. Nothing more, and on most other trials less. This is well known.(Reference: https://www.maps.org/sys/w3pb.pl?mode=search&c_pkey=23145&displayformat=allinfo&type=citation)
In theory the salvinorins could be easily complexed with B-CD or Y-CD by the same means mentioned in the cannabidiol paper that is attached. Precipitation from ethanol and water. The salvinorin could then be laid on blotting paper or impregnated easily into lamels for controlled dosages. The choice of the CD to use is a bit daunting due to the size of the molecule(salvinorin A), Y-CD may be the best option, though maybe B-CD would also work. It would be nice to know some of the relative dimensions in Angstroms of the molecule to get a feel.
In my opinion this is a very viable concept for adequate sublingual administration. As much as I would love to pave the way I have no access to salvia bio-mass as it was out-lawed where I live. However, for any other savvy experimenters I feel this could be of interest.
Cyclodextrins can be bought without hassle to my knowledge. They are commonly made through enzymatic means using a starch source(paper attached). The commercial availability of the CGTase enzymes is unknown to me. B-CD being the easiest to isolate because of it's miniscule water solubility. The product fabreeze also contains a hydroxpropyl-cyclodextrin which is another idea to work with, though I do not know of it's toxicity.
As it is known cyclodextrin(a,b,y,etc) complexation of molecules can improve bioavialability of some drug molecules via buccal(sublingual) administration. This is the case for certain nitrogen containing compounds such a 25i-NBOMe. A similar methodology has some-what recently been applied to cannabidiol a terpenoid(see attached paper for details).
Normally terpenes and many drug molecules have a hard time crossing into the blood stream by sublingual means. This can be aided by 'enclosing' these molecules in cyclodextrins. Cyclodextrins, or CD's for brevity, are essentially cylindrical sugar polymers. When a molecule is complexed with them the molecule fits inside of them like a ring to a finger.
The CD is the cylindrical shaped molecule.Note this image is not a completely accurate depiction of the goal but it is demonstrative
(Image taken from wikipedia)
The issue with extracted Salvinorin(s) is that they aren't really active sublingually. From personal experimentation I obtained a come-up of a salvia experience lasting maybe 20 seconds, as did a friend of mine. Nothing more, and on most other trials less. This is well known.(Reference: https://www.maps.org/sys/w3pb.pl?mode=search&c_pkey=23145&displayformat=allinfo&type=citation)
In theory the salvinorins could be easily complexed with B-CD or Y-CD by the same means mentioned in the cannabidiol paper that is attached. Precipitation from ethanol and water. The salvinorin could then be laid on blotting paper or impregnated easily into lamels for controlled dosages. The choice of the CD to use is a bit daunting due to the size of the molecule(salvinorin A), Y-CD may be the best option, though maybe B-CD would also work. It would be nice to know some of the relative dimensions in Angstroms of the molecule to get a feel.
In my opinion this is a very viable concept for adequate sublingual administration. As much as I would love to pave the way I have no access to salvia bio-mass as it was out-lawed where I live. However, for any other savvy experimenters I feel this could be of interest.
Cyclodextrins can be bought without hassle to my knowledge. They are commonly made through enzymatic means using a starch source(paper attached). The commercial availability of the CGTase enzymes is unknown to me. B-CD being the easiest to isolate because of it's miniscule water solubility. The product fabreeze also contains a hydroxpropyl-cyclodextrin which is another idea to work with, though I do not know of it's toxicity.