Made a new batch this time adding 4 grams of  of HPBDC for every gram of salvinorin. 200 mg of HPBCD and 50mg of Salvinorin where dissolved in 60ml of 75% ethanol and complexed by evaporation in a shallow tray.

This time I finished the evaporating in an oven at the lowest convection setting (170F). I don't recommend everyone start putting ethanol in the oven even at the lowest temp, use your judgement. In my case I cook with alcohol and sometimes flambe stuff so I felt safe and comfortable. Motivation for oven drying was to drive any ethanol interacting with HPBCD away and to have some heat during complexation.

I took 33mg of complexed HPBDC sublingually. Very intense wich is surprising. Of the 33mg assuming perfect complexation, only 7mg of salvinorin tops where bioavailable, or about 3g of dried leaves. That amount of dried leaves is supposed to be a light experience. This is well beyond light. It was intense. I'm glad I was conservative as I almost took 50mg to begin with. Maybe I'm developing reverse tolerance as I go through these experiments.

One observation is that I scraped up 180mg of powder. Was expecting 260mg. I attributed this to poor/lazy scraping by me, but maybe something else is going on. I'll do an experiment with HPBDC to make sure it does not dry out under heat to a smaller mass (not expected but I'll check).

Bottom line is that once again salvinorin became sublingually active after complexation by drying in an 75% ethanol cosolvent. Heat and thorough drying recommended as the second batch seems to be more potent (better complexed?). Also scraping was easier this time and was done on the warm shallow container while still warm from the oven. A lot of experiments including those where we measure the degree of complexation still need to be done.