Thanks Zebbie, that is interesting :thumb_up:

I want to do more work on cyclodextrin complexation, which seems reversible if heated. Want to thank all of you for being paitient.

It looks like complexed salvia does work, but it needs to be evaporated at low temperatures to achieve good complexation. It is a simple procedure, mix the extract with everclear and cyclodextrin powder and evap at room temp over a fan.

There a lot of questions such as how much has completed? Should the mix/dry process be repeated a few times to complex completely? Do we need a certain salvinorin/HPBCD ratio to maximize complexation? Does salvinorin need to be pure to complex properly without other stuff getting in the way?

I found good results: complexed salvinorin was active when drinking it. I think that was marvelous. physics envy had some promising results, but at the end of the day the crude uncompled extract and the complexed extract seemed similar in activity (for me the uncomplexed extract was not active). This may be due to different sensitivity and/or different amount of terpentines on our extracts.

I've promised physics envy a follup-up and that is coming. Salvia plants are happy growing outside. I also got thymeleaf sandwort to test too, see if we can make an effective complexed salviauasca.

Also, there are glaucoma drugs delivered with HPBCD as eye drops. Not telling anyone to try this but that would be a new ROI complexation may open up one day.