Attaching a new 2018 paper that used HPBCD to improve a the bioavailability of a drug.

The paper uses TLC to check complexation. Also measures a spectra, which we may be close to doing with home Raman. It then uses NMR to propose how the complexed drug looks (and some nexians have shown NMR results for DMT).

To form the drug complex they mix it and evaporate it (they do it in acetonitrile under alkaline conditions before going back to ph7). Anyone know why they used alkali conditions? Do they simply need the drug to be lipophilic so it slides into the cyclodextrin cavity? Makes me want to add ammonia to the everclear/salvinorin mix as a test.

It's a very nice paper for anyone interested in the subject.