It seemed pretty stable over a couple of weeks. I have a tiny bit of 1 year old complexed salvinorin in the pantry I need to test again by drinking. Since HPBCD can stabilize some drugs for long term storage maybe it protects salvinorin too.

The one thing that made it innactive was redisolving it in hot water. One possibility considered was that the heat kicked out the salivnorin from the complexed structure. That is why physicsenvy was saying that we are going to try again, this time evaporatating the alcohol/water/HPBCD/salvinorin dispersion at room temp with a fan.

Regarding the pH during complexation, I think we will want to target/test a pH where the molecule is neutral. Being neutral may help it get into the HPBCD lipophilic ring center. Will run the chemichalize demo to see what that pH is in water (I can't find a pka for salvinorin A). Will need to be careful since as you say some functional goups can break down at certain pH though. Not sure how it will work though since as we evaporate the pH can change. Hopefully simple neutral distilled water works.