When I was younger I suffered from mild depression, however after my first DMT breakthrough it vanished completely, I've also become a far more positive and happy person in general, and have a renewed love for this life, though the experiance itself was fairly traumatic, it was high dose, and I was not trying to cure anything, I was just curious, and incidentally cured my depression, I also doubt that you could treat depression with high dose DMT, but in my case it worked.

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Sorry if this goes off topic, but there was a tryptamine compound marketed as an anti-depressant...alpha-ethyl-tryptamine.

( AET was also the center of a drug analogue court case in Denver involving a dealer selling the compound as MDMA)

(This compound also has potential as an aide to withdrawal for opioid addicts)

-eg