There is no real need to inject DMT. 1.) Your DMT though very pure is not pure enough to shoot into a vein. 2.) If you do not use super sterile, one-time use works like disposable needles and a filter (damn even a cotton ball might help) pre injection as well as a steri-wipe for injection site, a steri-cup for solution preparation, etc. you risk toxic reactions, injection point infections and so much more.
Seriously, just weigh out a solid dose of fb crystal, then use a reliable and solid delivery device like GVG or e-mesh and do your best to get it in deep into your lungs, get it ALL in or as much as possible in that first hit and hold it 10-20 seconds. Exhale, VERY quick recovery breath if needed. IMMEDIATELY repeat until the hit is clear or you loose the room/device.
What's injection going to offer that smoking cannot? 0.4 seconds faster crossing the blood brain barrier? I mean both ROA's deliver to active transport at the BBB within a couple breaths at the most. And after thousands of exposures, I've had some crazy things happen, but I've never wound up in the hands of police or medical professionals during or after a smoked DMT session.
Many people assume that intravenous (IV) administration is the fastest way to deliver a drug to the brain... In fact, vaporized (inhaled) administration is always faster in terms of onset.
The reason being with IV, even in the case of a rapid bolus dose, the drug must travel through the veins to the heart, then to the lungs, and finally to the brain. In contrast, vaporized drugs enter the lungs directly and from there reach the brain rapidly via pulmonary circulation. So in terms of speed, vaporization is always faster than IV for achieving peak brain concentrations. Which is directly proportional to the intensity of the experience..
The limitation with vaping is not the speed, but the dose: you're restricted by how much you can inhale in a single breath, and how many inhalations you can reasonably take. IV doesn’t have that limitation; dose can be much higher and is only limited by the infusion rate. However, this becomes irrelevant for highly potent substances like DMT or 5-MeO-DMT, since it is easy to overdose and take too much even in a single inhalation or two, if executed with proper technique.
In my experience, a standard IV dose of these substances takes roughly as long to reach peak effects as two or three inhalations. So if the goal is simply a rapid and intense breakthrough experience, vaporization remains the most effective and practical route. That said, I’ve found that increasing the intensity through faster onset or higher doses doesn’t necessarily enhance the quality or value of the experience. I've explored several routes of administration (ROA), and the most meaningful breakthroughs often come from something else entirely, the blessing we really have when it comes to DMT is MAOI....
Even if you could control the rate of administration perfectly, this combination fundamentally changes the experience in a way that IV alone, even with perfect control, cannot replicate. Both due to the ability to extend the onset and metabolism as well as the synergy between the two itself... The effect of synergy is well known and reported by many but I believe that the effect MAOI has simply changing the metabolism dramatically alters the experience as well which is often attributed to MAOI and synergy but in reality it has its own dramatic effects on its own..
The experience itself is deeply influenced by the time it takes to reach peak concentration. For instance, if a dose reaches its peak in 2 minutes, the result is usually a very intense, fast onset and a similarly rapid comedown. On the other hand, if that same dose reaches peak over 30–45 minutes, the experience is longer, slower to build, and usually more integrated.
Certain substances like DMT or ketamine have well-defined experiential regimes: the "breakthrough" with DMT or the "K-hole" with ketamine. These often require a fast and concentrated onset. However, some of the most meaningful and valuable experiences lie outside these extremes... in slower, more controlled ascents and descents.
Controlling the rate of onset and offset is complex and molecule-specific. Short-acting compounds like DMT metabolize quickly, which makes sustained high plasma concentrations difficult without continuous infusion or MAOIs. This is why IV drip is used in clinical ketamine treatments: its short half-life allows for prolonged effects without dangerous accumulation. But IV drips are impractical outside of clinical settings and can be uncomfortable due to constant attachment.
Intramuscular (IM) administration is a reasonable compromise. It offers slower absorption than a bolus IV injection, peaking in about 15 minutes, yet it's still fast enough to trigger an immersive experience. For ketamine, this is why IM is often the preferred route: IV administration can be too rapid and disorienting, while IM allows for more gradual immersion and integration during each stage of the experience.
The key insight here is that the speed of onset can dramatically alter the nature of the experience. It’s well-known that there’s a threshold speed necessary to trigger a DMT breakthrough or ketamine K-hole. But faster and more intense isn’t always better. Many users mistakenly believe that if “fast and high” produced a breakthrough, then “faster and higher” must be better, this is not the case.
The sweet spot is somewhere in-between,
a balance where the onset is fast enough to induce the desired state, but slow enough to allow awareness and integration. Unfortunately, due to limitations in how most substances are administered, we often only experience either ultra-fast or ultra-slow onsets, and rarely anything in between.
However, there are ways to explore this middle ground. 5-meo-DMT is a perfect example, most users only know it experience that comes from vaporization... and due to the higher potency of 5meo-dmt relative to N,N-DMT, the rapid onset and rapid intensity that comes with it is even MORE PRONOUNCED and exaggerated... rarely can one experience what a breakthrough dose of 5-meo-DMT is like with a slower onset... since it doesn't have the option that DMT has of combination with MAOI for a slower onset oral dosage... like the discussion you see in this thread for example :
Rectal 5-MeO-DMT administration route
IM provides a very powerful and meaningful experience which I have not been able to replicate by other ROA.. Recently, I've been investigating the use of 5-MeO-DMT in a special formulation using a mixture of salt and freebase, solvent, and cyclodextrin for a highly absorbable nasal spray formulation. This could potentially approximate the onset curve of an IM injection, offering a smoother yet potent experience. Nasal administration by itself is insufficient due to the poor absorption, and as a result requires high dosages, and while the optimal experience can certainly still be achieved this way, its rather inconsistent, because its very difficult to control the actual dose being absorbed, so its easy to overshoot and undershoot..
Ultimately, the ideal route of administration depends on your goal. If you're seeking a fast, intense breakthrough with minimal equipment, vaporization is unparalleled—especially for potent tryptamines like N,N-DMT or 5-MeO-DMT. But if you're exploring the full spectrum of possible experience, a meaningful experience... with deeper integration and prolonged introspection, a slower onset through IM or carefully controlled ROA is the way forward.
The point is to understand how timing shapes consciousness of the experience, the deepest experiences have the perfect storm combination of dose and onset.... ... dose is too high onset too fast, no experience, or not a useful one like our OP example..
With respect to the OP, exactly the reason why these ROA are discouraged due to inexperience and recklessness, for personal health but also not to mention its something that greatly damages the community as a whole when the media gets ahold of stories like that with people injecting drugs and ending up in the hospital. My post here is generally for information and for more in-depth discussion on the different possible experience themselves and what hasn't been explored and potentially what can be understood from it.. particularly this happens so frequently with inexperienced users because they are familiar dosing with vaporization/smoking, and so they load up 40-50mg of DMT or more, because they assume that is how much is actually getting to the brain when in reality its maybe 20-25% depending on technique.... with good technique a GVG or other suitable device it can be much higher like 70-80% so when it comes to IV a few miligrams makes a very big difference, 1 or 2 milligrams is the difference between an intense experience and a complete amnesia OD..
Personally, i've certainly had my share of overshoots, even when doing things in the most calculated manner, its unexplored territory.. for instance exploring the different high dose regimes of the synthetic N,N-dialkyl tryptamine analogs, in the beginning I wanted to know if DMT breakthrough experience was possible with these higher substituted tryptamines, which could not be vaporized due to their higher necessary dosages