I never had a breakthrough until I loaded up a bunch of DMT and went for 5 big hits. By the 3rd one, everything was dramatically changed. I decided to take another, and things were just going bonkers like "this is the end of the line" and I figured I never got that far while holding in a hit, so I might as well go for one more. Well by the fifth hit, the feeling of "impending doom" was in the air with the lamp saying "you've really done it this time" and the cable box just looking at me with a sort of pity. I had encountered this feeling of "impending doom" once before, and while I was frightened the first time, this time I managed to keep in mind that nothing really too bad happened the first time, so I had nothing to worry about. I think it was this thought that was stringing me along starting around after the 3rd hit probably. Anyway, it resulted in my first breakthrough which was incredibly magical, surreal and out of this world in the best of ways. I don't think I ever took that many hits again (I usually clear it in 1-2 now anyway), but yes, if there's enough DMT in the pipe to get you enough, taking a bunch of rips can really take you across the universe and back in style.