sonochemistry

[benzyme]

because there's more to sonication than just lysing cells

 

[Oncewas]

Thanks

 

[benzyme]

this stuff was pioneered in the 50's, but it seems like it's often overlooked today. I guess companies like S-A prefer it that way

and it isn't really taught in college chem.


btw...reduction of dmt oxide (under inert gas) with a dash of zinc may be done very rapidly and efficiently. this approach is extremely useful in reduction reactions.

 

[Xt]

Interesting, thanks. I also see that microwave's are being used a fair amount. That was news to me when i first saw it.

 

[benzyme]

*for informational purposes only (don't wreck your microwave)

 

[jmaxton]

btw...reduction of dmt oxide (under inert gas) with a dash of zinc may be done very rapidly and efficiently. this approach is extremely useful in reduction reactions.

Does this also imply that ultrasound could be a safer alternative to the usage of LAH, for example, in some or all of Shulgin's reduction reactions from PIHKAL? Sorry if this is a stupid question. I know just enough chem to know that I don't know much at all...

-JM

 

[jmaxton]

OK, now that I've read over the paper in more detail it appears that US just increases the efficiency of these reactions. So LAH would still be needed, but the yield would be greater using US. Does this sound accurate?

Would this also potentially apply to the LAH-free alternatives for these types of reactions? Some alternative approaches using safer reduction agents have been discussed elsewhere, but the general consensus seems to indicate that they're often low-yielding in comparison.

 

[coz42]

I have seen these used in the production of biodiesel and a certain company hielscher sells even the smallest apparatus at a whopping $6k. Though if alternative uses in reduction is SWIY approach than all is well in the world.

 

[benzyme]

Would this also potentially apply to the LAH-free alternatives for these types of reactions? Some alternative approaches using safer reduction agents have been discussed elsewhere, but the general consensus seems to indicate that they're often low-yielding in comparison.

Diborane is a relatively safer alternative, and is just as effective as LAH if not better.
also, Urishibara catalysts are safer alternatives to Raney catalysts for reductive alkylation reactions

 

[jmaxton]

Diborane is a relatively safer alternative, and is just as effective as LAH if not better.
also, Urishibara catalysts are safer alternatives to Raney catalysts for reductive alkylation reactions

Definitely way over my head (I'm not a chemist), but thanks for the response. I've always been fascinated by the art of molecular manipulation so you've given me much to ponder. Just to be clear, I'd never attempt any such syntheses because I'm so incredibly ignorant of basic lab technique and safety. But I enjoy understanding more about how it all works, so thank you.

-JM

 

[benzyme]

sry, tried to ul a pdf...i'll link to an awesome book involving sonochemistry. there is one which mentions production of carbon nanotubes, and even sonication of benzene for 24h at 0C...the product: buckminsterfullerene.

 

[benzyme]

http://dl.lux.bookfi.org/genesis/753000/7d955634b45695e9787c4bdf9cfaea35/_as/[Filip_M._Nowak]_Sonochemistry_Theory,_Reactions_(BookFi.org).pdf

quote, right click, select all in link, open in new tab

 

[1ce]

Neat-o! Looks like I'll be dusting off the homogenizer in the real near future

S-A only exists to make chem life as difficult (and expensive) as humanly possible imho.

 

[Shaolin]

Links die, Nexus is eternal (and I couldn't get it to work ala benzyme).

 

[downwardsfromzero]

Thanks, Shaolin. The website was in Russian and wouldn't work. I gave up but then...

And thanks, Benzyme for the interesting links :thumb_up:

 

[benzyme]

yw.
sorry about the link, i'm on iDevices, so i couldn't upload a pdf.