back on topic- from a scientific standpoint given everything i've read prior to this thread and from this thread, it would almost appear that a kappa-opioid receptor agonist has a more "commanding" control of the mind than those entheogens working on the seratonin system....thoughts?

it's interesting how Jorkest stated that it was as if the Salvia spirit USED the DMT.  could this be a righteous combo?  by engaging the seratonin system while concurrently firing up the kappa-opioid receptors...could this be a akin to firing up a second engine in the mind?  vovin, bufoman, benzyme.....you are all the brain gurus on this forum....any science-backed speculation?