69ron
Rising Star
So, last night SWIM had a few hours to himself and decided it might be a good time to try sublingual mescaline to see if it actually works. SWIM has tried it before and always swallowed it afterwards and it seemed to bring the trip on faster, but he wasn’t completely sure if any at all was absorbed sublingually or not.
To get to the bottom of this, he took a standard known dose of 60 mg of mescaline acetate, which was cleaned with MEK, and a very active oral dose for SWIM.
SWIM is quite the expert at using things sublingually. He mixed the mescaline with 60 mg of calcium carbonate, to bring the pH of the mouth near the pKa of mescaline, which will aid absorption.
He put the mescaline under his tongue and held it there tightly for 15 minutes. Then he spit it out and rinsed his mouth. None at all was swallowed.
About 30 minutes later a very mild tryptamine-like body effect was felt, almost undetectable. Shortly afterwards, it began to fade.
Apparently super large doses are needed for mescaline to be active sublingually. 60 mg of mescaline acetate is enough for SWIM to get mild psychedelic effects, very mild visuals, etc., but sublingually, it was barely enough to even feel it. SWIM can very distinctly feel mescaline acetate doses as low as 20 mg, especially when combined with coffee. But this was even weaker than that. So potency wise it was less than 1/3 as active as using it orally.
This was a very disappointing experiment. While it is active sublingually, it is extremely inefficient to take it that way. This means, it’s best NOT to let mescaline aborb at all in the mouth. It should be dissolved in juice or coffee so that it washes down into the stomach ASAP. Absorption through the mouth will cause the effects to be much weaker and so it should be avoided.
In order to get decent effects sublingually, you’d likely have to take 5-10 times the dose you would normally take, and if such a dose was accidentally swallowed, holy shit you’d be in for it.
I don’t think sublingual use of mescaline is at all useful. Maybe if dissolved in DMSO it might work better. That’s the last thing SWIM will try with mescaline. If that doesn’t work to give more potent effects, then he’ll give up on sublingual mescaline altogether.
To get to the bottom of this, he took a standard known dose of 60 mg of mescaline acetate, which was cleaned with MEK, and a very active oral dose for SWIM.
SWIM is quite the expert at using things sublingually. He mixed the mescaline with 60 mg of calcium carbonate, to bring the pH of the mouth near the pKa of mescaline, which will aid absorption.
He put the mescaline under his tongue and held it there tightly for 15 minutes. Then he spit it out and rinsed his mouth. None at all was swallowed.
About 30 minutes later a very mild tryptamine-like body effect was felt, almost undetectable. Shortly afterwards, it began to fade.
Apparently super large doses are needed for mescaline to be active sublingually. 60 mg of mescaline acetate is enough for SWIM to get mild psychedelic effects, very mild visuals, etc., but sublingually, it was barely enough to even feel it. SWIM can very distinctly feel mescaline acetate doses as low as 20 mg, especially when combined with coffee. But this was even weaker than that. So potency wise it was less than 1/3 as active as using it orally.
This was a very disappointing experiment. While it is active sublingually, it is extremely inefficient to take it that way. This means, it’s best NOT to let mescaline aborb at all in the mouth. It should be dissolved in juice or coffee so that it washes down into the stomach ASAP. Absorption through the mouth will cause the effects to be much weaker and so it should be avoided.
In order to get decent effects sublingually, you’d likely have to take 5-10 times the dose you would normally take, and if such a dose was accidentally swallowed, holy shit you’d be in for it.
I don’t think sublingual use of mescaline is at all useful. Maybe if dissolved in DMSO it might work better. That’s the last thing SWIM will try with mescaline. If that doesn’t work to give more potent effects, then he’ll give up on sublingual mescaline altogether.