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Sublingual psilocybin trials

Migrated topic.
I'm looking too to no avail. It seems they're primarily disolvable strips, so the psilocybin presumably is absorbed through those sublingual membranes, bypassing the gastrointestinal tract. But no mention of actual production method of the product.

One love
 
Voidmatrix said:
I'm looking too to no avail. It seems they're primarily disolvable strips, so the psilocybin presumably is absorbed through those sublingual membranes, bypassing the gastrointestinal tract. But no mention of actual production method of the product.

One love
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That'll be part of where they want to be making their money, on the patented delivery method.

I wonder if it involves HPBCD?
 
The attached review is the most relevant info I have been able to find.

Chitosan is mentioned and is interesting. It can be made into ~250nm size polymer spheres.

Maybe it is worth adding OTC chitosan to a mushroom tincture and test for sublingual activity 🤷‍♂️.
 

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Sublingual psilocybin was explored here years ago. Ice house was talking about successfully quidding mushrooms over a decade ago, and a number of us were using psilocybe tinctures both sublingual as well as snuffed with positive results.

Psilocybin is already active as a sublingual drug, so you will be looking for an increase in effect rather than simple activity.
 
Here's an idea for an experimental method. Would alkaline quidding of mushroom powder perhaps do the trick? A pinch of lime, a pinch of cornstarch and a pinch of powdered shrooms might be worth a try. I would suggest mixing with the lime immediately before quidding because psiloc~in becomes unstable in alkaline environments.

Chitosan is derived from chitin, and chitin is the principal structural material of mushrooms:
Chitosan is a linear polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit). It is made by treating the chitin shells of shrimp and other crustaceans with an alkaline substance, such as sodium hydroxide.
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Chitin is a long-chain polymer of N-acetylglucosamine, a derivative of glucose. This polysaccharide is a primary component of cell walls in fungi, the exoskeletons of arthropods, such as crustaceans and insects, the radulae of molluscs, cephalopod beaks, and the scales of fish and skin of lissamphibians. The structure of chitin is comparable to another polysaccharide, cellulose, forming crystalline nanofibrils or whiskers. It is functionally comparable to the protein keratin.
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Obviously, pure chitosan is readily available for purchase, but the intrepid (cheapskate) researcher will see that any one of a number of naturally-occurring materials (insect wings?) would be a pretty good source of fairly pure chitin. A simple pre-treatment with sodium - maybe even calcium - hydroxide followed by neutralisation should furnish some level of deacetylation. Besides that, some fungi produce a certain amount of chitosan as it is.

This looks like a good read for would-be chitosan nerds: https://www.sciencedirect.com/science/article/pii/B9780128179703000146
 
jamie said:
Sublingual psilocybin was explored here years ago. Ice house was talking about successfully quidding mushrooms over a decade ago, and a number of us were using psilocybe tinctures both sublingual as well as snuffed with positive results.

Psilocybin is already active as a sublingual drug, so you will be looking for an increase in effect rather than simple activity.
Click to expand...

I can attest, my experience with fresh mushrooms is that If I chew them throughouly and hole them in my mouth, the psychoactive effects are felt immediately albut subtle, lingering until the remainder of the alkaloids become active via oral route.
 
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