Hello. I felt compelled to share my experience with you after reading your intro. And welcome 
First of all I'll give you a little background on myself. I have been on and off opiates (pain meds) for the last 8 years due to fibromyalgia. Since this is not curable, I am depressed, so they give me anti depressants. To make a very long story short, I ended up addicted to the pain meds as well as numb from the anti depressants.
I have withdrawn several times from the opiates and a few times from the anti depressants, which reminds me so much of what you were talking about in your intro (feeling again, etc).
I am now in the process of weaning myself off the SSRI for the LAST time. I do not want to be numb anymore. I also have my bf control my pain meds so I don't go overboard with them and I only take a minimal amount to be comfortable.
With all of that said, I did DMT for the first time two nights ago. So personally, I don't think you need to have everything out of your system first. I had a life changing experience that night and it has made me want to be a better person. It has certainly made me see my flaws as a human, but it did not make me feel bad about them.
Anyway, in my personal opinion, I think doing the DMT will help you in your journey of whatever you are trying to get away from. If it is truly a spiritual experience you seek, I think it will be extremely good for you.
Welcome again 