Reading more into this plant, I've found something which is very interesting. In a paper http://sci.odu.edu/biology/directory/Motley_files/publications/Motley_Acorus.pdf which appeared in the journal of economic botany, vol 48, "the ethnobotany of sweet flag," I read that sweet flag has been used in India to reduce the side effects of other entheogenic plants.

Has anyone ever used this plant as an ayahuasca additive? I think some experimentation is in order.

The same claim is mentioned in this article Acorus calamus - Sweet Flag - Entheology.com