The highest DMT dose pharmahuasca

[ChrisMMcD]

I'm wondering how much of an oral DMT dose would be needed to achieve an instant breakthrough.
I tried 50mg and felt like I could handle more. My sweet spot seems to be around 60-80mg, but I'm still considering taking a higher dose. I haven't come across any forum posts about extremely high doses of pharmahuasca.

What do you think about taking a dose of 250-300mg of DMT? Would I be able to handle it, and what kind of experience could I expect? Could I potentially reach the same realm as when I vape DMT?
And more generally, what is the maximum safe and feasible oral DMT dose? I have an experience with 10g dry cubensis trips, with salvia divinorum too, so I'm not new to intense trips.

I'm curious to hear your thoughts.

 

[Voidmatrix]

I don't know if there is anyway for it to be "instant" considering that it has to be metabolized and enter the blood stream, which invariably takes time. You may be able to increase the harmala dose in order to get quicker onset. I don't think the amount of DMT will really increase the onset. Eating 3.5g of mushrooms seems to take about the same time to kick in initially as 7+ grams ime. It's just that the total ramping feels faster since one is going deeper with a bigger dose.

250-300mg sounds a bit risky, even with experiences with high dose mushrooms. They're just not the same. I'd recommend finding an interval you feel comfortable increasing by and take several journeys increasing by that increment each time to see how it suits you.

I have not seen anything on a safe maximum dosage for DMT aside from the LD50.

One love

 

[610nanometres]

I have not seen anything on a safe maximum dosage for DMT aside from the LD50.

Bit off topic, but this got me thinking. I don't know why, but I'd always just felt that dmt was something you couldn't physically overdose with, or actually harm yourself. Obviously, I'm not talking about damage to your psyche.
Found this paper Psychedelic 5-Methoxy-N,N-dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions and it says the LD50 in mice ranges from 48 to 278 mg/kg, depending on administration method.
Made me sad to think of the poor little creatures being purposefully killed with the spice, just to satisfy our curiosity.

As void says, oral administration would seem to preclude the possibility of 'instant' breakthrough.