I’m not saying that science knows nothing – that’s ridiculous. The best expression of what I’m saying is a quote from Lawrence Krauss’ talk:

We know and can observe things now that in the distant future will no longer be observable. This is a scientific fact.

But what’s interesting to me isn’t what will be unobservable in the distant future, but the fact that there might be unobservable phenomena right now. Of course, I can’t say what those “unobservables” might be, but it logically follows that if we can show that there will be unobservables in the future, then perhaps there are unobservables today. If that’s the case, then our lack of information may lead us to certain scientific conclusions that are completely wrong.

This is the primary limitation of science, and I don’t see any way around it: We must develop theories based on observations, yet there may be some very important and fundamental phenomena that cannot be observed. That’s a real problem.