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The natural production of DMT

Migrated topic.
M

mr.smiley

Rising Star
I was browsing the net about an adrenalin related fear and loathing topic, when I started to wonder. They cant prove or disprove that DMT is synthesized in our brains, but what they have found is that our brains do contain the necessary amino acids and enzymes to naturally create DMT and that it is present is our blood and urine.

So is it not possible or even plausible for someone to be able to clean up their diet to detoxify their body and ingest in some way, shape or form the basic building blocks our body uses to create DMT in excessive quantities to boost DMT production in the body as well as take a MAO inhibitor.

Then harness our bodies natural removal process, and extract our own natural DMT from our waste?
If this were not possible for the average human, would it not work with those suffering from schizophrenia and/or psychosis?


Ref:
www.sbs.com.au

DMT: The psychedelic drug 'produced in your brain'

DMT is an illegal psychedelic drug that produces a powerful hallucinatory experience, and it might even be produced by our own brains.
www.sbs.com.au www.sbs.com.au

Ask Erowid : ID 3146 : Is DMT produced in the human brain?

Ask Erowid Question and Answer: Is DMT produced in the human brain?
www.erowid.org


EDIT: I'm not debating weather or not DMT is produced/present/stored in the body but more along the lines of; can we boost production to a point where we can extract viable amounts from human urine.
 
In short, no.

FAQ - DMT Frequently Asked Questions and Troubleshooting Guide - DMT-Nexus Wiki

wiki.dmt-nexus.me wiki.dmt-nexus.me

As of yet, there is no proof of DMT being made in the brain. It seems to be made elsewhere. in the body, though in the future new experiments might show otherwise. Either way, it's there, in all of us :)

In the 'endogenous dmt:facts and fiction' thread you can read about quantities found in our bodies, they are much smaller than what's needed for psychoactive experience, and the DMT is metabolized by MAOs and CYP enzymes. If after that, anything is excreted unmetabolized, it would be in extremely low concentrations. You won't be able to extract usable quantities from urine. You'll probably have more luck finding plants in your area that contain DMT.

As of boosting the production (regardless of trying to extract it), some people hypothesize it might happen under certain circumstances but AFAIK we have no controlled scientific experiments to date exploring this idea so we'd just be speculating one way or another.

Lastly, as usual again there is a focus on DMT, while our body produces a host of other psychoactive compounds which people tend to ignore. I wonder why.
 
mr.smiley said:
I was browsing the net about an adrenalin related fear and loathing topic, when I started to wonder. They cant prove or disprove that DMT is synthesized in our brains, but what they have found is that our brains do contain the necessary amino acids and enzymes to naturally create DMT and that it is present is our blood and urine.

So is it not possible or even plausible for someone to be able to clean up their diet to detoxify their body and ingest in some way, shape or form the basic building blocks our body uses to create DMT in excessive quantities to boost DMT production in the body as well as take a MAO inhibitor.

Then harness our bodies natural removal process, and extract our own natural DMT from our waste?
If this were not possible for the average human, would it not work with those suffering from schizophrenia and/or psychosis?


Ref:
www.sbs.com.au

DMT: The psychedelic drug 'produced in your brain'

DMT is an illegal psychedelic drug that produces a powerful hallucinatory experience, and it might even be produced by our own brains.
www.sbs.com.au www.sbs.com.au

Ask Erowid : ID 3146 : Is DMT produced in the human brain?

Ask Erowid Question and Answer: Is DMT produced in the human brain?
www.erowid.org


EDIT: I'm not debating weather or not DMT is produced/present/stored in the body but more along the lines of; can we boost production to a point where we can extract viable amounts from human urine.
Click to expand...

You can probably boost endogenous DMT via. high protein diet (Tryptophan(amino acid) -> DMT)
Meditation, Exercise, MAO inhibition, etc.

I would like to see a urinanalysis done on people who meditate for extended periods like buddhist monks, etc.
I'm sure their blood (and consequently urine) is MUCH higher in endogenous DMT/psychedelics, in contrast to the average person.

As for elevating endogenous levels to create a sort of self-DMT-production-facility...
Hmm, how wonderful that would be!
However, if you did manage to elevate your natural levels that high (which is HIGHLY unlikely), I don't think you would even have much interest in extraction it from your urine. (You would be incredibly spaced out)

Also, can you link me to some evidence showing it is found in human urine?
 
it was cited in a review by Presti et. al 2004 "Endogenous Psychoactive Tryptamines Reconsidered: An Anxiolytic Role for Dimethyltryptamine".
that's a good start.

also, the tryptophan metabolic pathway favors serotonin production, a simple high protein diet, exercise, even meditation won't necessarily change that...although it's plausible the conditions leading to the "stress theory" may, temporarily.

I'd also consider endogenous beta-carbolines, people seem to overlook those..
 
benzyme said:
it was cited in a review by Presti et. al 2004 "Endogenous Psychoactive Tryptamines Reconsidered: An Anxiolytic Role for Dimethyltryptamine".
that's a good start.

also, the tryptophan metabolic pathway favors serotonin production, a simple high protein diet, exercise, even meditation won't necessarily change that...although it's plausible the conditions leading to the "stress theory" may, temporarily.

I'd also consider endogenous beta-carbolines, people seem to overlook those..
Click to expand...

I think there are a number of endogenous substances responsible for extraordinary experiences and it wouldn't be wise to overlook any. :)

A high protein diet could possibly create a more favorable foundation for DMT to be created, as it is created from Tryptophan Metabolism.

At this point all we can do is speculate it's (DMT) purpose and where it is produced, and then explore the ideas we create through scientific investigation.

Maybe DMT production is increased in a highly oxygenated enviornment when the Serotonin receptors are saturated? (Deep breathing increases blood oxygen concentrations)
Or maybe nitrogen has something to do with it.

Who knows.

Also, that was an interesting read!

"Furthermore, we suggest that endogenous DMT interacts with the TA receptor to produce a calm and relaxed mental state, which may suppress, rather than promote, symptoms of psychosis."
I found it interesting that they said Amphetamines, especially in low doses, have activity at TA receptor
 
lsDxMdmaddicThc said:
benzyme said:
it was cited in a review by Presti et. al 2004 "Endogenous Psychoactive Tryptamines Reconsidered: An Anxiolytic Role for Dimethyltryptamine".
that's a good start.

also, the tryptophan metabolic pathway favors serotonin production, a simple high protein diet, exercise, even meditation won't necessarily change that...although it's plausible the conditions leading to the "stress theory" may, temporarily.

I'd also consider endogenous beta-carbolines, people seem to overlook those..
Click to expand...

I think there are a number of endogenous substances responsible for extraordinary experiences and it wouldn't be wise to overlook any. :)

A high protein diet could possibly create a more favorable foundation for DMT to be created, as it is created from Tryptophan Metabolism....

Maybe DMT production is increased in a highly oxygenated enviornment when the Serotonin receptors are saturated? (Deep breathing increases blood oxygen concentrations)
Or maybe nitrogen has something to do with it
Click to expand...

the problem with that is extracellular DMT found in peripheral tissues would be rapidly metabolized by MAO-A.
again, serotonin production is favored, not DMT.
 
benzyme said:
lsDxMdmaddicThc said:
benzyme said:
it was cited in a review by Presti et. al 2004 "Endogenous Psychoactive Tryptamines Reconsidered: An Anxiolytic Role for Dimethyltryptamine".
that's a good start.

also, the tryptophan metabolic pathway favors serotonin production, a simple high protein diet, exercise, even meditation won't necessarily change that...although it's plausible the conditions leading to the "stress theory" may, temporarily.

I'd also consider endogenous beta-carbolines, people seem to overlook those..
Click to expand...

I think there are a number of endogenous substances responsible for extraordinary experiences and it wouldn't be wise to overlook any. :)

A high protein diet could possibly create a more favorable foundation for DMT to be created, as it is created from Tryptophan Metabolism....

Maybe DMT production is increased in a highly oxygenated enviornment when the Serotonin receptors are saturated? (Deep breathing increases blood oxygen concentrations)
Or maybe nitrogen has something to do with it
Click to expand...

the problem with that is extracellular DMT found in peripheral tissues would be rapidly metabolized by MAO-A.
again, serotonin production is favored, not DMT.
Click to expand...

Well the body has endogenous MAOI's so I don't think you can completely rule that out.
 
benzyme said:
that was my point, mentioning endogenous beta carbolines are worth further consideration.
i've said that for years.
Click to expand...

Oh, sorry I misunderstood.
I think that they are definately worthy of investigation.
The time to ponder is now, we must work towards deeper understanding perhaps from a fresh point of view?
 
benzyme said:
the problem with that is extracellular DMT found in peripheral tissues would be rapidly metabolized by MAO-A.
again, serotonin production is favored, not DMT.
Click to expand...

Could you not retain a high level of MAOI's in your system threw a regimented diet rich in natural MAOI's?
 
mr.smiley said:
benzyme said:
the problem with that is extracellular DMT found in peripheral tissues would be rapidly metabolized by MAO-A.
again, serotonin production is favored, not DMT.
Click to expand...

Could you not retain a high level of MAOI's in your system threw a regimented diet rich in natural MAOI's?
Click to expand...
And, of course, ayahuasca covers both bases...

(Sorry for being a smartass :roll: )
 
And, of course, ayahuasca covers both bases...

(Sorry for being a smartass :roll: )[/quote]

Yes you could just take aya, but that is a completely different solution to what the proposed idea asks...
We are not trying to take DMT to blast off here or create a concoction in the body to make it get you there, but amp the production, whilst suppressing the bodies natural form of breaking it down with MAOI's, which should lead to elevated levels excreted in our urine.
Giving us a potential(little or not) source for DMT if the crack down on plants containing this chemical became a serious issue.
 
endlessness said:
Lastly, as usual again there is a focus on DMT, while our body produces a host of other psychoactive compounds which people tend to ignore. I wonder why.
Click to expand...


Can you be specific as to which compounds you are referring to?
DMT, 5-Meo-DMT and bufotenine are all endogenous beta-carbolines if I am to understand, but the few others I was able to find showed no positive feedback into being psychoactive.

That being said, the small amount of research out there on these chems, what ever they are can only stand for caution in dealing with which is unknown.
 
In My experience, cleaning up the body as well as possible, for some reason unknown, resulted in Spiritual Experiences almost on par with DMT/NMT excursions.
The best way I can describe it is that sometimes when going out with Spice, there would be a 'deja vu' type of feeling similar to remembering being in a Dream.
Fasting and then cleaning out with anti-oxidant natural foods is intense. Almost too intense for many People, as the toxins coming out like to beat you up first before they go. The body goes a little 'haywire', having had these poisons inside for so long and getting acquainted and used to having them around so, when they leave, it feels to the Mind like you are losing a Best Friend or even as if you are going through a divorce or something.
This only last for a week, maybe two but then after that, the 'Clarity' comes.
We are Naturally Attuned to the Environment, Nature, The Universe and once We get all the 'Junk' out that was clouding Our Minds and Binding up Our 'Wiring and Antennae's', that all comes back and this is where a 'Test' of Mind and Spirit comes in because :
Can Ones 'Self' HANDLE being back 'In Tune' with it all after being under for so long?
One feels like a 'Kid' again, almost. Like anything is possible and the 'Boogie Man' could even be in the closet again or under the bed.
I believe the Pineal Gland , the Area of Our Mind said to produce natural DMT and also know for being another 'Eye' accept it has no 'lense', it awakens again and Dreams, even Hypnogogic and Lucid, start happening.
This can be a 'Shock' to Us, since We have been in the 'Matrix' for so long.
However, I Belive it is one of the Best Things We can do for ourselves and the only trick after pulling this off is to STICK WITH IT and don't go back to whatever those substances were that were clouding up the Mind, Body and Spirit in the first place.
That would be 'Returning to the Matrix'.
The foods I use[d] to clean out and to stay clean are both cheap and expensive and some I even go out and pick Myself, like Goldenrod, Dandelion, Cloves ...
Some, it is better to purchase, like Spirulina, Wheat and Barley Grasses, Bee Pollen....
Some you cad do yourself or by, like Basil Oil both Orally and Transdermally.
I don't know if you know about Basil Oil but it has Psychedelic Properties to it as well if you can get it to activate.
One method is to keep applying it Transdermally on the hour for a week.
By the time you get to 48 hours, you could be tripping nicely. 69ron has a lot about this here: Nature's Herb Forum-The Psychedelic Effects of Sweet Basil Oil (Methyl Chavicol)
I wouldnt do this unless I had the free time to do it but it IS one way, if used with the above ingredients and clean non-fluoridated water, to clean out quickly and safely, resulting in an 'Awakening'.
Everyone reacts differently to this and sadly, many can't take it and go back to ingesting junk again.
The 'Cleaner' one is, the more DMT is activated, thats MY Experience anyways. THC is still a favorite. DMT/NMT, LSD, Shrooms ... ALL that too. Nicotine, to a minimum.
Plenty of healthy food but there are times, slipping back to old habits happens and One has to clean out the attics again!
I learned all of this through years of research and thats my experieces. Hope this helps.
Peace!
 
benzyme said:
mr.smiley said:
DMT, 5-Meo-DMT and bufotenine are all endogenous beta-carbolines if I am to understand
Click to expand...

you understand incorrectly..those are all tryptamines. beta-carbolines are tricyclic compounds, pyridine fused to indole.
Click to expand...

Yes sorry, I reread the article. Misread a paragraph...
"Some beta-carbolines have been detected in the tissues and fluids of mammals, including humans, where they are thought to be produced from endogenous tryptamines such as serotonin, 5-methoxy-tryptamine and tryptamine itself."
 
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