There is an entourage effect with many plants which is why I personally prefer teas over 'pure' extracts of compounds. However with chemistry I'd expect this to be a lesser issue unless there are unreacted compounds and iso- forms that remain from each step. I'd assume there is a purification step at the end and the amount of times done will increase purity at the cost of lost product? Even terpenes in weed modify thc. Pure compounds are interesting however sometimes leads to undesirable effects like PURE thc vs in mixture with cbd.

Even with other plants like psychotria vs pure d with cappi. There is something missing with pure extract vs with plant teas. The oils and other minor compounds do have an effect IME. IDK if true with Smoked or other forms of ingestion/application

I remember reading there are some lsd iso forms that are inactive but perhap modify receptors?