I personally would tend to think that this depends a lot on yourself.

E.g. I get quite some motion sickness from Harmalas during the first 1-2h as well as a sedating effect.

DMT OTOH to me has quite a strong body freezing effect. I quite quickly get disconnected from my body and outer reality and dive into the inner worlds.

But I'm well aware that this isn't the case for some other people. That's why I think it all depends on the individual and set&setting.

Also the question is not only will you be too immobilized and capable to hike, but also will you be inspired at all to go hiking.

I could certainly think it could be interesting to do after some time after the peak, when coming down, as then IMHO it resembles strongly a shroom state.

But this is just me, interested to hear others' viewpoints.