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Tolerance or "immune" to DMT?

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flotsam

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Does anyone know what might make a person either highly tolerant of DMT or partially "immune" to its effects?

I helped a friend over the weekend with a trip (his first ever DMT). I used 40mg in an e-mesh vape, and he barely had any visuals at all. Certainly below threshold. I then increased the dose to 70mg and he had some decent closed eye visuals but definitely didn't break through.

I used the same batch I use and extracted myself, so I know the product was good quality. Using this batch and vape set up, I usually use 15mg to get a good threshold experience for myself, and 30mg for a guaranteed breakthrough (25mg is usually enough). He is of similar weight and build to me.

He was in a fasted state other than caffeine and not on any medication that he admitted to.

He did say he tends to have a high tolerance for other substances like cannabis and MDMA but is fine with LSD and Psilocybin.

Anyone come across this before or have any ideas? 70mg vaped at a good temperature and all consumed seems to me like a massive dose that should have done the trick for sure, so I'm confused.
 
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This is somewhat rare but definitely not unheard of. Other than body constitution, period of eating before the journey and other drugs taken, there's also sensitivity of their nervous system and general tolerance to the endogenous effects of exogenous materials as well as capacity for experience. For me, the last point in most poignant, reason being that there is a great deal of neuro and cognitive diversity as to the capabilities and capacities of other minds. As an example, not all individuals have a visual memory capacity.

My advice: SMOALK MOAR. It's hard to overdose, see how 90mg-100mg suits them :) :twisted:

One love
 
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flotsam said:
Does anyone know what might make a person either highly tolerant of DMT or partially "immune" to its effects?

I helped a friend over the weekend with a trip (his first ever DMT). I used 40mg in an e-mesh vape, and he barely had any visuals at all. Certainly below threshold. I then increased the dose to 70mg and he had some decent closed eye visuals but definitely didn't break through.

I used the same batch I use and extracted myself, so I know the product was good quality. Using this batch and vape set up, I usually use 15mg to get a good threshold experience for myself, and 30mg for a guaranteed breakthrough (25mg is usually enough). He is of similar weight and build to me.

He was in a fasted state other than caffeine and not on any medication that he admitted to.

He did say he tends to have a high tolerance for other substances like cannabis and MDMA but is fine with LSD and Psilocybin.

Anyone come across this before or have any ideas? 70mg vaped at a good temperature and all consumed seems to me like a massive dose that should have done the trick for sure, so I'm confused.
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Hmmm I've always thought this was more related to like how some people can remember their dreams better while others can't. However there are practices you can do like dream recall therapy and lucid dreaming, and other meditative practices to help sort of open these doors in your brain up. I've often wondered if people who struggled with this would benefit from trying some of these techniques.

There is also another term I've often thought applied to this problem which Is aphantasia. Aphantasia is where you don't have the ability to picture something in your mind. Like try picturing a bird for example, how well can you see the bird in your head? If you can see an image of a bird in your head you don't have aphantasia but if you can't then you may possibly have this.

aphantasia

i believe like the article states that aphantasia is not a disorder or a disability but more closely related to right hand and left hand mechanics. I believe that aphantasia exists on a spectrum and that you could train your mental eye to start seeing visuals or imagery. it is about excersising and practicing imagination which in this highly technological overstimulating world can be hard to remind yourself to excersise the imagination.






There is also a link between aphantasia and being on the autistic spectrum so I've often always wondered if this could be related to undiagnosed autism in a lot of the reports of people who aren't on meds and haven't done anything to give themselves an unreasonable tolerance.



Autism and Aphantasia



That's not to say that OPs friend is on the spectrum or anything just throwing ideas out here for possibilities I've considered on this phenomenon. People can have aphantasia who are not on the spectrum as well.




another thought is that DMT is something that is naturally occurring in our body so it'd make sense that biological factors could influence how your brain receives and interprets it.

similar to how our body has cannabanoid receptors and some users will not experience a high from cannabis no matter how much they smoke for their first couple sessions.



newer video revealing some interesting finds for brain imaging with DMT





Best of luck to your friend OP!
 
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Was he very anxious for the trip? Anxiety can give a bad trip or no trip at all sometimes, if he resists too much. Already happened to me.
Is he a weed smoker? Some people don't know how to give a good toke too, weed is good for practice.
 
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I'm very curious (and honestly a little scared) about this phenomenon. It's really strange that some people are just immune or become immune to the effects of psychedelics for no apparent reason. If you have an update on this, please do share, I'm curious to know if he was ever able to experience hyperspace 'as intended.'
 
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I have a friend who seems to be almost entirely immune to tryptamines also. It's extremely peculiar. He told me he bought rather a lot of liquid acid and consumed it and felt almost nothing. I thought the L was just sub-par quality and those kind of arguments, so I gave him a bunch of Cubensis which did nothing to him. An occasion after that, I gave him 5g dry Ps. Cyanescens which he ate while doing office work at home one afternoon, said he got something from that, but more like being mildly drunk and uplifted rather than the face-melting ride he should have expected. He is going to get a little shot at some DMT, but I fear that sadly the outcome will be much the same

He is not on any SSRI meds etc that would interfere with the pharmacological action of tryptamines so I am at a bit of a loss to explain it, but I am aware there is data showing a small number of people from DMT and psilo studies to be immune to the effects

Hopefully I can report back with good news...
 
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I have this happen to me, it’s one of the reasons I’m here. I can eat a THC infused edible in massive doses 1000mg with absolutely 0 effects. I can lemon tek 3g of dried cubes and just barely get the walls breathing and the duration is extremely short. I come down off a mushrooms like a bottle rocket.
 
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SingularFusion said:
I have a friend who seems to be almost entirely immune to tryptamines also. It's extremely peculiar. He told me he bought rather a lot of liquid acid and consumed it and felt almost nothing. I thought the L was just sub-par quality and those kind of arguments, so I gave him a bunch of Cubensis which did nothing to him. An occasion after that, I gave him 5g dry Ps. Cyanescens which he ate while doing office work at home one afternoon, said he got something from that, but more like being mildly drunk and uplifted rather than the face-melting ride he should have expected. He is going to get a little shot at some DMT, but I fear that sadly the outcome will be much the same

He is not on any SSRI meds etc that would interfere with the pharmacological action of tryptamines so I am at a bit of a loss to explain it, but I am aware there is data showing a small number of people from DMT and psilo studies to be immune to the effects

Hopefully I can report back with good news...
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SSRI's and 'anti-psychotics' taken over years can incapacitate your psychedelic receptivity for LONG periods of time, like up to decade.

This also has implications perhaps like, would children growing up on SSRI's or antipsychotics develop deep resistance to psychedelic or entheogenic experience?

Also why is it that I see people running around on a tab of acid at events or something and for me a tab of acid is like blowing my emotional and perceptual socks off like holy crap respect, beauty.
Am I super sentitive?
Do I have like, 'a ton of active internal trauma' that they don't?
Or are they not sensitive somehow? Or are they experienced?

The dose is not everything of course ... there is also the adventurer communing with the spirit molecules.
only talking about pharmocological scientific etc dose:strength stuff might also undermine some of that other side of things.
 
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flotsam said:
Does anyone know what might make a person either highly tolerant of DMT or partially "immune" to its effects?

I helped a friend over the weekend with a trip (his first ever DMT). I used 40mg in an e-mesh vape, and he barely had any visuals at all. Certainly below threshold. I then increased the dose to 70mg and he had some decent closed eye visuals but definitely didn't break through.

I used the same batch I use and extracted myself, so I know the product was good quality. Using this batch and vape set up, I usually use 15mg to get a good threshold experience for myself, and 30mg for a guaranteed breakthrough (25mg is usually enough). He is of similar weight and build to me.

He was in a fasted state other than caffeine and not on any medication that he admitted to.

He did say he tends to have a high tolerance for other substances like cannabis and MDMA but is fine with LSD and Psilocybin.

Anyone come across this before or have any ideas? 70mg vaped at a good temperature and all consumed seems to me like a massive dose that should have done the trick for sure, so I'm confused.
Click to expand...
Has he committed suicide and survived before?

My first time doing DMT it had no effect other than paralysis.
Second time was like first steps taken on the moon.
My first time doing 5meo-DMT the toad,
it also had no effect other than paralysis for 45 minutes.
The second attempt immediately after the first failed attempt I took 4 times the recommended dose.
Causing my heart to stop... Briefly.
The only answer I ever received was because I had committed suicide and survived before
ever taking DMT.
Which made sense since it's the chemical released when you're born and when you die.
No priests or scientists are yet to give me an answer and am still personally seeking an answer.
 
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