physical exercise is one of the best medicine's. ayahuasca can be, but someone has to be ready. It's speculated that MDMA destroys serotonin receptors. The brain is flexible anough to recover and to grow new receptors. You can encourage this by entrainment; expose her to situations that require serotonergic activity; social situations, humour, fun. Repeatedly doing things she actually enjoys will make her learn to enjoy life more and more. It's the best way to train the 'enjoy' muscle.