Bufotenine is an active hallucinogen dithy, it just has some really unpleasant side effects due afaik to the pKa of the compound...
Anyway, its not very psychedelic but it is quite visionary/hallucinogenic.
I dont beleive the Mayans were using 5-MeO-DMT toad secretions. It makes perfect sense they were using Bufo Marinus toad secretions instead. The toads were actually available in the region-unlike Alvarious.
After many experiences with bufotenine maybe 10 years back I concluded that the mayan imagery around the toad to me is most clearly represented in the bufotenine visions, or vice versa. The only reason we have the Alvarious theory is because ppl like Wade Davis ran with unfounded speculations, while claiming bufotenine was a non active toxin-which was total bs and these researchers had zero experience with the compound...and only some really shotty prison experiments Leary did injecting bufotenine salts into inmates as an alkaloid salt.
Make sure you convert it to a base.
We already know, in the jungle, there is a tradition of visionary shamanic use of bufotenine alive and well. This 5meoDMT toad myth and idea that bufotenine is just a toxin is one I would have hoped would die by now, but too many self proclaimed toad shamans want you all to believe make believe.
So, yes it it is active.
It def combines with other typtamines, but I want to add that my opinion is that bufotenine can actually reduce quality of a good DMT, psilocybin or LSD trip. It will increase visions, but for myself bufotenine can really make the mental space feel fuzzy, almost washed out a bit. Mentally it felt like sleep deprivation a bit. Some will say nausea is avoided, but not at any useful dose for myself. If I was able to get around the nausea it would be inconsistent-in that next time I would still get sick.
I would only use bufotenine when the objective is to fully hallucinate or visualize. If you want psychologicl insights/healing, this was never the compound. Again, this is of course just my experience. I can acheive full blown cosmic travel type OBE's with bufotenine and these are among the most visionary experiences I had had.
Vine and rue deepen it, and add a welcome opening into a more psychologically rich experience. They can both reduce some of the side effects and enhance others so go slow and expect sickness unlike DMT brews.
Dont drink the stuff...or if you do you have been warned lol.
Smoking Bufotenine is the oldest known method, followed by snuffing and I suggest you experiment in that order.
Combines with psilocybin etc as well, but all the same rules apply...expect strong open and closed eye visions, nausea and vasoconstriction.
I would avoid sublingual, you probly dont want to swallow any bufotenine until more familiar with it's effects.
