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Use of colchicine in entheogens

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Rising Star
I was just reading about the effects of colchicine on dna and was wondering if possibly salvia divinorum could made viable seeds if modified with colchicine.

Furthermore I was curious if there were any alkaloid / oil constituent variation as we see for example in hemp versus cannabis. I also notice considerable variations in calamus diploid, triploids.

Is there anything unethical about the use of colchicine in entheogens?
 
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