This vary much personally. Me, 200 mg rueHCL there comes a brief moment I (not necessarily but) better lay down for 15 minutes, not trippy but stoned-foggy-ish, and a nice long afterglow. A friend is like wutt? I only feel some stomach going on for the rest nothing much.

No need for a full day off, just reserve the first 4 hours for potential foggy-ness, after that an afterglow which should not prevent doing stuff. Just my thoughts.