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What i have been experimenting on myself lately.

Flufferus

Flufferus

Esteemed member
Donator
This is very unsafe, but i check my vitals frequently and have EMT training.

I am taking harmala's with Citralopram, Olanzepine, and Entresto plus Carvedilol.

I made a citrate pharmahuasca tincture that i regularly dose out of Rue and some DMT.

I am able to sleep at night, some "brain zaps" happen, but i keep myself in bed incase the worse would happen and i have a seizure.

I am doing this for scientific purposes.

This has been going on for about a week so far no issues.

If this is against the theme of the site, feel free to talk to me and delete this post.

Thank you for reading.
 
I am not a medically educated person. However I suggest that you be very careful, perhaps even refrain from mixing MAOIS and SSRIs. I have read that life threatening toxicities may occur. I am sure you know this. What do you expect to gain from this experiment? We don't want to lose you.
 
Let's take a look at these drugs:

Harmalas
-Mostly inhibit MAO enzymes, elevating dopamine, serotonin, and epinephrine(oftentimes epinephrine to a lesser extent), etc

Citalopram
-SSRI does as SSRI does
This is instantly making your serotonin receptors NUMB.

Olanzapine
was used for schizophrenia treatment, and psychomotor schizophrenia situations
-direct serotonin 2A, 2C, 3A antagonist, serotonin 1 inhibitor
-D1-4 antagonist
-histamine H1 receptor antagonist
-alpha adrenergic receptor antagonist
-acetylcholine M1-M4 receptor antagonist
-GABA inhibitor
My thoughts: you might as well IV superglue into your brain. The dopamine antagonism will slowly make you develop ticks so get off of it. This drug seriously depresses you and seems like it could be contra indicatory to the heart failure medications, but idk. Not to mention it blocks you from experiencing psychedelics !

Entresto (Sacubitri/Valsartan)
Used to treat heart failure...
Is there a specific reason why you mention that you are on this?

Carvedilol
Used to treat chronic heart failure, hypertension, and left ventricular dysfunction*
Beta-1 adrenergic receptor antagonist
Alpha-1 adrenergic receptor antagonist
and acts on many other related receptors to lesser degrees.
Again, is there a specific reason why you are taking this? You don't want to mess with your cardiac rhythm. This drug gets right up in there into your QT interval. You want to be careful not only being on it, but also going off of it.


So, first of all I hope that if the heart meds are necessary, then you would let us know that in some way! Secondly, if you are trying out the antipsychotic (olanzapine) on dr's orders, or simply have it lying around and are curious, be careful. Chronic consumption of antipsychotics are extremely toxic to your emotions. Harmalas that you are taking are not very strong, or acute. They are chronic small doses as far as it seems. harmalas are very systemically powerful, and and affect many cognitive systems. Your brain, and body, cannot function dynamically under such a broadly inhibiting and chronically administered load. You are suppressing so so so much or your being. Regardless of what your experimental intent is, I hope this experiment comes to a close soon. You should not be having zaps at night. Those are coming from the antipsychotic for sure. Also I forgot, you are taking DMT? Are you tripping at all? xD

❣️❣️❣️❣️❣️
 
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You need to be particularly wary of the harmala metabolic interactions. This can affect efficacy and clearance of your medications.

Carvedilol, for example, is partly metabolised by CYP2D6, so its elimination half-life, and consequently its peak plasma concentration, is likely to become elevated. This does not seem to be optimal; harmalas have a vasodilatory action which may exacerbate the hypotensive effect.

Similar considerations should be applied to the other medications - if there's already a risk of hyperkalemia, raising the concentration of the causative agent would be further cause for concern. I've seen claims that harmalas can deplete magnesium - this action would also be potentially dangerous in combination with elevated potassium.

I'd be interested to know how you came up with this idea. Hearing more about the etiology of your heart problems might be too much of an ask, but it provides context for a possible grounds to use Syrian rue. I'm not convinced of the wisdom of combining it with all the pharmaceutical medications.

All the signs point to it being better for you to lay off the harmalas, unless perhaps you're getting some fairly comprehensive bloodwork done for a scientific study.
 
Flufferus said:
This is very unsafe, but i check my vitals frequently and have EMT training.

I am taking harmala's with Citralopram, Olanzepine, and Entresto plus Carvedilol.

I made a citrate pharmahuasca tincture that i regularly dose out of Rue and some DMT.

I am able to sleep at night, some "brain zaps" happen, but i keep myself in bed incase the worse would happen and i have a seizure.

I am doing this for scientific purposes.

This has been going on for about a week so far no issues.

If this is against the theme of the site, feel free to talk to me and delete this post.

Thank you for reading.
Click to expand...
These combinations wouldn’t pass the ethics committee, and to be realistic this is not doing it for science, you’re talking a very risky combination of medicines and harmalas that shouldn’t be combined. I worry for your health and implore you to only continue your experiment with and in full cooperation with your health care provider.

Much love
 
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I understand personally that some people need to be on strong medication to function, so I hope you don't feel stigmatized by some of the response. Many of us on the forum are on antipsychotics and do trip. I would be wary of seratonin syndrome with everything else. Psychiatrists tend to pile things on, so maybe with the harmalas you will be able to wean off of the riskiest ones. Read "Learn From My Mistakes" in my signature and reach out if you want to discuss more.
 
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@Transform i am getting some bloodwork done soon, the doctors want me on a plethora of psych meds, its interesting you bring up low magnesium levels, because i supplement heavily with magnesium malate. what prompted me to do this, was to see if serotonin syndrome actually exists. i even took a tagamet at one point to see how it would all affect me.
 
Yes a condition of living at my current residence is being on antipsychotics. I made my harmalas with dmt pretty strong so it shines through all the olanzepine a alittle bit, but i will concede not very much. i dont like being on the olanzepine, but as it is a thenobenzodiazepine i am rather addicted to it. i like to call it space xanax...
 
@Flufferus - check this out:
en.wikipedia.org

Selenoneine - Wikipedia

en.wikipedia.org en.wikipedia.org
en.wikipedia.org

Ergothioneine - Wikipedia

en.wikipedia.org en.wikipedia.org

The latter compound occurs in (besides ergot!) golden oyster mushrooms, the former in various kinds of seafood. The both appear to have measurable cardiovascular benefits, and selenoneine is listed as an ACE inhibitor…

Hilariously, this organism:
Mycobacterium smegmatis - Wikipedia
is listed as being capable of producing ergothioneine. If the Latin name of this bacterium wasn't sufficient of a hint, it seems "genital secretions (smegma)" could be used as a health supplement :ROFLMAO:
 
Transform said:
@Flufferus - check this out:
en.wikipedia.org

Selenoneine - Wikipedia

en.wikipedia.org en.wikipedia.org
en.wikipedia.org

Ergothioneine - Wikipedia

en.wikipedia.org en.wikipedia.org

The latter compound occurs in (besides ergot!) golden oyster mushrooms, the former in various kinds of seafood. The both appear to have measurable cardiovascular benefits, and selenoneine is listed as an ACE inhibitor…

Hilariously, this organism:
Mycobacterium smegmatis - Wikipedia
is listed as being capable of producing ergothioneine. If the Latin name of this bacterium wasn't sufficient of a hint, it seems "genital secretions (smegma)" could be used as a health supplement :ROFLMAO:
Click to expand...
thank you for sharing that, my "test" of "myself" seems to have bore fruit afterall. i have no idea what im onto, but it seems clinically relevant.
 
a common side effect of being on Olanzepine is infection of the perennium or the skin between sexual parts and sphincter. one could assume that the metabolites of olanzepine provide a breeding ground for these bacteriums. this is all speculation of course on my part. Olanzepine makes one not want to move at all really, hence producing more smeg...

oh dear...

i will start to bathe more often.
 
@Flufferus my heart goes out to you so much, and I feel very powerless so far away across the internet to have any real chat with you. I have a had extensive experience with mental health professionals and I wish you would only take a break from as many of these meds as you can. Give your body the healthiest lifestyle you can give it, so that it can manifest itself healthily
 
Flufferus said:
a common side effect of being on Olanzepine is infection of the perennium or the skin between sexual parts and sphincter. one could assume that the metabolites of olanzepine provide a breeding ground for these bacteriums. this is all speculation of course on my part. Olanzepine makes one not want to move at all really, hence producing more smeg...

oh dear...

i will start to bathe more often.
Click to expand...
Well that was a somewhat uncanny intuition!

The perineal infection tendency sounds like a side effect of sitting around, as much as anything! This very much ties in with the demotivation you describe.

A dear, departed friend of mine was on Olanzapine and, while he put on a ton of weight at least partly from the drowsiness (not to mention a diet of pizza on top of restricted mobility after a RTA), it did seem to help stop him from randomly attacking cops.

Yeah, bootstrap yourself whatever way you can - being kind to yourself and getting into a personal hygiene routine would make an important part of that. Cessation of antipsychotic medication is a tricky one, I'd say, since the last time that my late friend stopped was immediately prior to his relapse into paranoid psychosis. It's a shame that it has such anti-motivational effects.
 
Transform said:
Hope it wasn't too messy/painful!

Were there any specific points you'd care to share on why you've concluded it's unwise? Are you an experienced boofer of other substances?
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yes, i used to boof other substances. it was unwise to boof that because it was the strongest dmt citrate i could make. i could barley get it into the boof apparatus. Luckily i used only safe chemicals to make it, such as organic orange extract.
 
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