I don't have experience personally, answering from a chemical perspective and based on anecdotal experiences. DMT freebase is non-polar, while PG is polar. Meaning DMT does not dissolve very well into PG. PG prefers a hydrogen bond with itself, rather than interacting with the DMT.
It seems like below 200mg/ml the solution is stable and doesn't recrystallise, whereas pushing towards or above 250 mg/ml increases the likelihood of crystallisation.
See:
DMT solubility in Propylene Glycol (PG) - Advanced/Enhanced chemistry - Welcome to the DMT-Nexus
and:
Vaping with e-cig juice - Welcome discussion - Welcome to the DMT-Nexus
Assuming we can somehow make it work with 300 mg/ml (e.g. by keeping it in a warm place and heating it in the cart already - I believe this should be possible, but once it cools down it will likely recrystallise and clog up).
For your 0.5 ml cart, that would mean it could contain up to 150 mg of DMT (roughly 0.15ml) to 0.35 ml of PG.
Assuming that from your 0.5 ml cart, you could get about 50 big puffs before it runs empty. That means that per puff, you would get about 3mg of DMT, which isn't much. I don't feel like it would be possible to get a breakthrough that way - and freebase is harsh so taking such big hits might even be challenging.
Some things to consider:
- Use something else than PG as solvent. I've heard of people trying PEG-400 or different ratios PG/VG (there is a discussion in one of the threads linked above), but I think it's options are also limited / might only improve it by a little.
- Coil configuration (e-mesh seems popular) and voltage used (more voltage -> more material burned -> higher dose). Your options when using a cartridge (as opposed to e-cig) might also be more limited there.
My personal thoughts:
Based on the math, the dose of DMT from a 0.5 ml cart would likely be too far off from reaching a breakthrough dose. Even if you manage to push the concentration up to 300 mg/ml or even 350mg/ml, which could work as long as the solution is kept warm, it still seems like the maximum dose per puff would be too low. The 3 mg per puff might be enough for some minor effects, but it would be far from the intense experience associated with a breakthrough dose.
Even with the potential to tweak the solvent choice, coil configuration, or voltage settings, the dose you’re able to achieve from a cart just seems too far from the required amount. While small improvements could help, it feels almost impossible to make that leap to an effective breakthrough dose, especially with the limitations of the system.
Additionally, if the solution does recrystallize and clog up the cart, it can be frustrating to try and recover the DMT. It might be difficult or impossible to salvage the material once it's clogged, making the whole process potentially wasteful and a bit cumbersome.
So, in short, while this method might work well for light or gentle effects, it’s unlikely to deliver the intense or breakthrough experience many are seeking. Additionally, the clogging issue could add an extra layer of frustration.