Wow! Mescaline has antinociceptive properties?!?

[LawnBoy]

http://www.springerlink.com/content/r362405777578758/
So, mescaline and morphine seem to have a cross-tolerance.

http://toxipedia.org/display/toxipedia/Morphine

"To understand the power of morphine to affect the brain one should point out that the B-phenylthylamine unit, is also central to affecting the brain in hallucinogenic molecules as well. Morphine shares the unit with LSD and mescaline. Morphine and its analogues differ from hallucinogens because they have narcotic, pain relieving, sleep-inducing effects."
Is this how one can explain mescaline having a cross-tolerance to morphine, and mescaline's antinociceptive properties?

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0C-475BDDG-89&_user=10&_coverDate=11%2F30%2F1972&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1262398365&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=b0a267fcb5c15067c913674439533e7c

While, mescaline and THC don't seem to have a cross-tolerance.:?

Low dose combination of morphine and delta9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors - PubMed

Morphine and delta9-tetrahydrocannabinol (THC) produce antinociception via mu opioid and cannabinoid CB1 receptors, respectively, located in central nervous system (CNS) regions including periaqueductal gray and spinal cord. Chronic treatment with morphine or THC produces antinociceptive...

www.ncbi.nlm.nih.gov

Chronic administration of morphine or THC produced antinociceptive tolerance to the respective drugs, whereas combination treatment did not produce tolerance.:d
So can I assume that mescaline does not control pain, the same way that THC controls pain?

Anandamide - Wikipedia

en.wikipedia.org

THC most likely gets its antinociceptive from its effect on anandamide and the TRPV1 vanilloid receptor.

 

[69ron]

So, mescaline and morphine seem to have a cross-tolerance.

That's the first time I heard about that. That's interesting. Do any other hallucinogens have such a cross-tolerance with morphine?

 

[LawnBoy]

Opioids and Hallucinogens

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-475JBJB-2YC&_user=10&_coverDate=02%2F28%2F1986&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1262518096&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=08f06cbd45dafa98c30144d0e60fb4f3

www.angelfire.com/alt2/fizzacyst/opiod-hallucinogen_interaction.pdf

http://www.scribd.com/doc/13370808/JV-Wallach-Endogenous-hallucinogens-as-ligands-of-the-trace-amine-receptors-A-possible-role-in-sensory-perception

Opioids and Salvia

Shaw Communications

www.members.shaw.ca

Morhine and Anti-cholinergics

Cross-tolerance between morphine and cholinergic blocking agents microinjected into anterior amygdala

WE have previously demonstrated tolerance to repeated applications of opiates microinjected directly into the amygdaloid region of the brain<SUP>1</SUP>. Since morphine has been shown to inhibit the release of acetylcholine at some brain sites<SUP>2,3</SUP>, as well as in the isolated guinea pig...

adsabs.harvard.edu

Morphine and Ketamine

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0C-478NBHC-68&_user=10&_coverDate=10%2F31%2F1989&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1264434283&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a32b555a95b6f0615d3d64978210613f

Morphine and Ibogaine

Sex differences in ibogaine antagonism of morphine-induced locomotor activity and in ibogaine brain levels and metabolism - PubMed

The present study demonstrates that the putative antiaddictive agent ibogaine produces more robust behavioral effects in female than in male rats and that these behavioral differences correlate with higher levels of ibogaine in the brain and plasma of female rats. There were no differences in...

www.ncbi.nlm.nih.gov

http://content.karger.com/ProdukteDB/produkte.asp?doi=28246

http://www.springerlink.com/content/w02w117210420544/

Ibogaine effects on naloxone-precipitated withdrawal from morphine

Morphine and MDMA

Prior experience of morphine application alters the c-fos response to MDMA ('ecstasy') and cocaine in the rat striatum - PubMed

Repeated morphine application usually leads to the development of tolerance but under certain circumstances sensitization may arise simultaneously. This phenomenon becomes obvious in behavioral tests as increasing locomotor activity and increasing drug self-administration during a course of...

www.ncbi.nlm.nih.gov

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T07-408C11J-7&_user=10&_coverDate=04%2F14%2F2000&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1262458983&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=52ea47c26fe6280d4badf6a447b391ff

Painkillers : MDMA ( Ecstasy )

http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=194230

http://cat.inist.fr/?aModele=afficheN&cpsidt=20183844

www.lycaeum.org/research/researchpdfs/1989_crisp_1.pdf

Morphine and DMT

http://www.springerlink.com/content/l2364480lnh776v4/

Inquiry | Grit Brokerage

www.opioids.com

http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=160285

http://www.lycaeum.org/drugs/abstracts/L4.cgi?kwand=DOMINO&max=100&mode=newlex&simple=simple

http://ajpheart.physiology.org/cgi/content/abstract/00193.2002v1

“...morphine... has been known that it is a natural endogenous neurotransmitter in higher vertebrates":shock:

http://www.salviasource.org/forum/psychoactive-encyclopedia/you-are-illegal-illegal-drugs-you-naturally-produce/?wap2

Should I change the title to this post?
Should it be moved to another section of the nexus?
You should see my face right now. It's a mixture of awe and joy. I love google.

 

[soxy bastard]

They have a mild cross tolerance and a somewhat pronounced potentiation when taken together for a completely different type of experience than either alone. It is an excellent combination for healing sessions with patients in a lot of pain. as a purpose driven combination IMO it has a lot of potential for terminal patients and other chronic pain situations.
As a common analgesic low dose mescaline is mildly stimulating and non hallucinogenic at doses >100mg but is as effective on pain as 10mg of Oxy for me. But for days when pain reaches "severe" A 1/4 dose of tar and 30mg oral morphine will last all day long into the evening w/o feeling "doped" and keeping a good energy level as well as a good attitude.
Huge potential in analgesia and as a "cocktail" drug for a number of conditions
SB

 

[benzyme]

serotonergics in general have antinociceptive properties.
tramadol has weak affinity for mu (o-desmethyl-tramadol has 100x the affinity), but is also a 5HT reuptake inhibitor. this latter activity gives it additional analgesic properties