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1-propionyl-lysergic acid diethylamide

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Continuum said:
Have you read Dale Pendell's Pharmakognosis? He hung a sign over the door reading, "Demons welcome here." Metanoia is doing Pendell proud lol.
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Interestingly enough, I have not. I know what I'm doing this weekend :D :thumb_up:

Ufostrahlen said:
Sure, do whatever you have to do. But with these RCs, bear in mind that there's only a rumor of a pro drug, I haven't found a single official piece of 1P research. Not that the propionyl group magically triggers severe vasoconstrictions @ 400µg or something.
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That is exactly what draws me to it, the edge of the map where beyond this point "there be monsters" 😉 I don't advocate foolish guinea pigging but I think it may be time to take it a bit further and see what this beauty can do. Not official research persay, but useful nonetheless :)
 
Its Psykinetic's. Sits above the door to his bedroom on the frame.

Pendell had a huge impact on him when he started the journey back from junk, and he made this either right before or right after his first aya analogue brew that shook him free of a long habit, made using Pendel's brew recipe from Pharmako, iirc.
 
Wow, 50µg and I'm tripping. No entities, but tripping. Semihyperspacial.
 
Tattvamasi said:
Ufostrahlen said:
Wow, 50µg and I'm tripping. No entities, but tripping. Semihyperspacial.
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8)
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Haha, quite funny in a weird way. Tried to use it as a lucid dreaming agent at 2:00 night. Bam... :shock:

Even trippier as with the 100µg... granted I'm on less benzos right now.

Edit: Noobs be careful: this stuff is potent! Expect vasoconstrictions even at this low dose.
+12:00 - still noticeable effects, especially in the fingers...
 
Found this:

We asked David E Nichols a few questions regarding this subject. Dr Nichols is the founding president of the Heffter Research Institute, a non-profit that researches medical uses for of psychedelic hallucinogens. He has been working in the psychoactive field since 1969, and was involved in the first human trials for MDMA under Alexander Shulgin.

Is 1P-LSD a prodrug to LSD?

David Nichols:

It is a prodrug, and is hydrolyzed in the body to LSD. A publication just came out in Drug Testing and Analysis.

Can a prodrug be more potent than their parent chemical?

David Nichols:

No, a prodrug won’t generally be more potent than the actual parent drug. In some cases, e.g. heroin, which is a prodrug for morphine, will get into the brain faster and at a higher concentration than morphine will; 10 mg of heroin would have more effect than 10 mg of morphine. But that is the exception.

As a prodrug, 1P-LSD becomes similar to LSD in its effects only after it’s been metabolized. While the debate for which new drugs will take over the market rages on, this interesting analogue of an old favorite is making its presence known.
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So...? Do we know if he is right? And what does it mean if he is?

Is 1P-LSD metabolized to LSD-25 and becomes active or is it already active on it's own, then beeing converted to LSD which is also active?

A comment from a reddit discussion on this article, which makes sense to me:

It's definitely possible for a pro-drug to be more potent / quicker onset than the drug it produces, but it isn't typical. From a biological point of view this is usually because the pro-drug is capable of crossing the blood brain barrier more efficiently which can lead to a higher concentration in the brain. Once in the brain, then it's metabolized. Like Dr. Nichols mentioned above, this is seen with heroin and morphine. Heroin crosses the BBB more efficiently and turns into morphine. You can also find examples of this in cigarettes. There are chemicals in cigarettes that modify pH (I think lung pH but I genuinely can't remember - it's been awhile since I went over this mechanism) which helps nicotine cross the BBB. Not good for you lungs of course, but you feel a little bit higher than you would otherwise.
I don't know what's going on with 1P because it seems like, from anecdotal reports, that it's quicker and slightly more potent. Could be for any number of reasons really. It makes sense to me that 1P could be active by itself and simply metabolizes into LSD as well. The propionyl group could make the molecule slightly more hydrophobic which would help it cross the BBB, but I don't know for sure..
Edit:
A few people down below are claiming 1P lasts longer than LSD. If that's the case, then the above model makes sense in my mind. The propionyl group slightly improves hydrophobicity and membrane transport. 1P gets into the brain quicker and at a higher concentration. Converts to LSD. You perceive 100 ug of 1P to be stronger and last longer than 100 ug of LSD because you are literally getting a slightly higher dose of LSD.
Of course, that's making some assumptions. We don't even fully understand how LSD works, let alone 1P-LSD.
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25 µg and I get good references of LSD space. Can't sleep and 3 mg of melatonin don't work either. :shock: I really wonder what the REM sleep supporting dose is... 12.5µg??
 
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