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1-propionyl-lysergic acid diethylamide

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You're welcome, let's begin researching! :thumb_up:
 
Reports on EU boards are rather positive thus far. Pro-drugs have a bad history of easily falling under the US federal analogue act, as there's a fair bit of federal appellate court decisions treating GBL as a schedule 1 analogue of GHB, before GBL was specifically scheduled; the prime rationale being that GBL converts, in vivo, to GHB. I have no idea if this 1P metabolizes into a scheduled compound or not, and tend to think it wouldn't have been brought to market in the EU if it did.
 
Hey All,

Just wondering if anyone has anything to share regarding 1p LSD.

Is it at all different from LSD ? If not, how does it differ ?

Any thoughts appreciated greatly :)
 
JustCurious. said:
Hey All,

Just wondering if anyone has anything to share regarding 1p LSD.

Is it at all different from LSD ? If not, how does it differ ?

Any thoughts appreciated greatly :)
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Out of interest, I have searched the web for info and trip reports of this compound the past few days.
The general consensus for now seems to be that it is probably not a prodrug of lsd after all, but that it is very similar in terms of effects:

It has been theorized that 1P-LSD may be a prodrug to LSD. Despite this prevailing theory, however, it appears that this is likely untrue. It has both a shorter duration, subtly distinct subjective effects and an extremely close potency which are three things which are rarely associated with a prodrug (especially in combination).

The effects of 1P-LSD are almost identical to that of its close structural relative LSD with the differences being so minuscule they are almost negligible or primarily due to different responses within the tripper.
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Source

There doesn't seem to be a clear picture of experiential differences between 1P-LSD and LSD.
This is the most in-depth comparison I have found so far, but it is of course just one person's single experience:

I dropped 100ug of 1P-LSD this weekend. I won't go into great detail on the experience, as I don't currently have the time, but I will say, as has been said before, that it is very hard to distinguish between 1P- and normal LSD.
The only slight differences I noticed were the come up, duration, and come off. The come up was a bit more intense. More than usual 'anxiety' feeling. A bit more pressure in the chest, which I always get coming up on LSD, and I felt a bit shaky during the first 1hr - 1.5hrs. I was mildly physically shaking actually. Nothing too bad.
The duration was huge for me. LSD usually lasts around 12hrs for me, sometimes more until everything wears off. 1P-LSD lasted a few hours longer for me. I dropped it at around 11am - 12pm, and at 3am I was still getting enhanced colours, slight spacial distortions, LSD thoughts.
When I went to bed just after 3am, I experienced quite mild closed-eye geometric patterns. I found them less intense and flashy than the ones I get on LSD. It was quite pleasant and I fell asleep not too long after.
I found my sleep better than on LSD. The next day I was quite wiped out, but that's usual. I noticed less emotional issues than with LSD 'hangovers'. I usually get a bit depressed and easily annoyed. I was a bit out of sorts but definitely not as bad as with normal LSD.
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But if it is not a prodrug and the 1-propionyl will not fit the receptor site as Nichols claims, how else could its psychoactivity be explained?
 
ॐ said:
But if it is not a prodrug and the 1-propionyl will not fit the receptor site as Nichols claims, how else could its psychoactivity be explained?
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My guess: autosuggestion or undiscovered hallucinogenic mechanisms?
 
I materialized some 1P-LSD, yay! Redundant trip report won't follow. 😁
 

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Took another 200ug dose of this blessed molecule last weekend...

It is a beautiful, beautiful beast. :love:

Have a lovely time. :thumb_up:
 
This stuff is the real deal. 100µg and everyone on the forum knows, what I'm talking about. Mu.
 
Maybe it's the 2mg of Diclazepam and the 20mg of Oxazepam that I took with the 1P, but I say there's no paranoia going on whatsoever. Took a walk around the block and everybody behaved peaceful. The cars were a little bit noisy tho, let's hope Tesla fixes that soon. But the shiny colors they gave off compensated for the noise. :d

Oh and I think you can enter the entity realm with this one, if you dare to go higher. Not sure if it's lethal - if it's a pro drug like Dave Nichols said, then probably not. But better play it safe kids!
 
I'm wondering how this would go along with harmalas... I predict it would be as beautiful as regular LSD but only time will tell with this beast...
 
Metanoia said:
I'm loving that this is available now, it really is something special :love:
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Stock up, kiddos! 😁

Godsmacker, I'd say let it do its thing uninhibited until you know that space alone.

Like Ufostrahlen, my experience of the 1P is that there's no paranoia.

It's crystal clear, a really lucid experience of the trip. Being in the Moment with it.

I took kratom the same day, cause I take kratom every day, but I don't think it altered the clarity or calm of the trip.
 
I also noticed no paranoia to speak of. I went out for a walk to the park in the moonlight and it was breathtaking. :love: I understand the cars being loud because music appreciation was heightened to a ridiculous level for me.

Ufostrahlen said:
Oh and I think you can enter the entity realm with this one, if you dare to go higher.
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I do so dare good sir :twisted: If there shall be monsters, count me in :lol:

Continuum said:
Stock up, kiddos! 😁
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Already ahead of you :lol:
 
Metanoia said:
Ufostrahlen said:
Oh and I think you can enter the entity realm with this one, if you dare to go higher.
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I do so dare good sir :twisted: If there shall be monsters, count me in :lol:
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Sure, do whatever you have to do. But with these RCs, bear in mind that there's only a rumor of a pro drug, I haven't found a single official piece of 1P research. Not that the propionyl group magically triggers severe vasoconstrictions @ 400µg or something.

I actually found 25I @ 500µg pretty safe, too. I couldn't imagine that people can die from higher doses, although it already gave off hints of vasoconstriction @ 500µg. And 500µg was already a blast. I mean, spirit realms are all nice and sweet, but better try it with safer chemicals like DMT & Co.

A small comparison of 100µg 1P to 150µg AL-LAD. Maybe it was the setting, or the Benzodiazepines or the right dosage, but 1P is way friendlier than AL-LAD. The walls were moving and breathing with 1P, too, but with AL-LAD I was floored for some hours and the netbook display looked like a giant psychedelic crystal. Just too overstimulating for a pleasant trip.

With 1P, everything was cool and sweet and I think the legality of a substance hugely influences the trip as well. It's legal here to possess 1P, so I didn't mind walking the streets and smiling at strangers. :) Walking upright helped the image of a friendly and sane citizen.

Binaural beats go well with the upcome of the trip! 😉
 
Have you read Dale Pendell's Pharmakognosis? He hung a sign over the door reading, "Demons welcome here." Metanoia is doing Pendell proud lol.

I totally concur with your assessment of AL-LAD to 1P, Ufo. At 300ug of 1P I had the clearest experience of my life. At 300ug of AL-LAD, I was awash in a sea of vortexes, and it was a bit much in a fun-house crazy way. I'm not going that high in dosage with AL-LAD again, while I am certainly going to go up to 500ug with the 1P, when I have the perfect set and setting.
 
Continuum said:
Have you read Dale Pendell's Pharmakognosis? He hung a sign over the door reading, "Demons welcome here." Metanoia is doing Pendell proud lol.

I totally concur with you assessment of AL-LAD to 1P, Ufo. At 300ug of 1P I had the clearest experience of my life. At 300ug of AL-LAD, I was awash in a sea of vortexes, and it was a bit much in a fun-house crazy way. I'm not gong that high in dosage with that one again, while I am certainly going to go up to 500ug with the 1P, when I have the perfect set and setting.
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Nope, I haven't... I'm not in the mood for the spirit realms anymore. But tell us what 500µg of 1P is like. Save travels!
 
I totally concur with you assessment of AL-LAD to 1P, Ufo. At 300ug of 1P I had the clearest experience of my life.
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i second that, 300ugs of 1P and 200mg of caapi alks was the clearest HD'ist time i have ever had without DMT, if i sat and stared i would have full on DMTesque visions of outrageous clarity, it was epic.
 
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