I would say that when used in conjunction with a high enough dose of harmalas (and depending on the physical/mental/emotional makeup of the user in question) it's probably possible.
Keep in mind that the term "breakthrough" is only a subjective linguistic representation for what we experience, and it likely means different things to different people. There are a myriad of factors involved that will either allow or deny one access to that space (i.e. technique, set/setting, etc.), but for moi, it really comes down to a dose dependent response (meaning with all other things being equal, a perfectly vaporized 10mgs will provide one level of experience, 20mgs will provide another, and so on and so on and so on). I've yet to find a ceiling (or bottom, depending on how you look at it...), but for me (sans harmalas), it takes something around 35-40mgs to achieve complete ego loss - which is usually what I think of as breaking through.